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- W2187454166 abstract "Severallines of investigationpoint to differences in electrical properties betweennormaland cancerous cells. Severaltumor lines havelow-restingmembranepotentials.A few comparisons have been made between normal and tumor cells within the same tissue cell type. This study compares the cellular or transmembranepotential of hepatocytesand fibroblasts in both normal and tumor cells. High-impedance micropipets were used to record intracel lularly in vivo in Buffalo rat hepatocytes and Morris 7777 hepatomacells, as well as A/J mousecorneal fibroblasts and poorly differentiated fibrosarcoma cells. Rat hepatocytes had a mean membranepotential of —37.1 ± 4.3(S.D.)mVcomparedto —19.8 ± 7.1 mVinthehepatoma cells. Mouse corneal fibroblasts measured —42.5±5.4 mV, while cells of mousefibrosarcoma were — 14.3 ±5.4 mV. The membrane potentials of the tumor cells were lower in both instances than in their normal counterpart (statistically signifi cant at p = 0.001 for both tissue cell types). This supports the notion that lower cellular or membrane potentials may play a significant role in the altered physiology of the tumor cell." @default.
- W2187454166 created "2016-06-24" @default.
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- W2187454166 date "1980-01-01" @default.
- W2187454166 modified "2023-09-27" @default.
- W2187454166 title "Cellular Potentialsof Normal and Cancerous Fibroblastsand Hepatocytes" @default.
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