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• W2187470411 abstract "Tissue engineering has recommended the development of biomaterials for implantable porous scaffolds at the injured site, which temporarily acted as the supporting materials for ingrowths of the cells and degraded along with extra cellular matrix production, vascularization and tissue regeneration. Usually, three dimensional scaffolds play the most important role in the design of Tissue Engineering Construct that affects the cell fate process. Natural Polymer biomaterial such as Collagen, Keratin mimics the extra cellular matrix at the site of injury for regeneration of tissue. Collagen is one of the protein biomaterials and already prominently placed in the development of tissue engineering contructs.But due to poor environmental conditions, Collagen denatures into gelatin which lost triple helix conformation and also affects the cell fate process. Keratin is one of the fibrous proteins found in the extra cellular matrix, providing outer covering such as wool, hair feathers and nail and alternative to collagen biomaterials. The presence of high cysteine content in the keratin helps to immobilize the bioactive molecules for drug delivery application. The extracted keratin from horn meal is made into the macro porous scaffold by freeze drying method. The molecular weight of extracted keratin was determined by SDS.Poly acryl amide gel electrophoresis and was characterized by CD spectroscopy, FTIR. The scanning electron microscopy studies of macro porous Keratin scaffold confirms that the scaffold has interconnectivity heterogeneous pores that will help to bind with drugs or cells for design of drug delivery systems and tissue engineering constructs." @default.
• W2187470411 created "2016-06-24" @default.
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• W2187470411 date "2012-01-01" @default.
• W2187470411 modified "2023-09-27" @default.
• W2187470411 title "Research Article Macroporous Keratin Scaffold - a Novel Biomaterial for Biomedical Applications" @default.
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