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- W2187474184 abstract "Objectives. Cytokines play an important role in pathogenesis of atherosclerosis. The aim of this study was to esti− mate the level of TNF−α and its relationships to the levels of some other factors potentially involved in atherosc− lerosis progression in alcoholics during early abstinence period. Material and Methods. We studied 47 alcohol dependent male patients who stopped alcohol misuse period not la− ter than two weeks before the study beginning. In all at the study start and after 4 weeks abstinence we determined the levels of: tumour necrosis factor alpha (TNF−α ), plasma lipids, platelets count and their mean volume (MPV) and total antioxidative status (TAS). These examination we repeated in 27 subjects who turned−up at 6−month vi− sit, among their only 17 remained abstinent. Results. In studied alcoholics more or less 50% had determinable (> 0.05 pg/ml) TNF−alpha level at all three visits. This cytokine concentration decreased with time of abstinence duration. Alcoholics with determinable TNF−α level (n = 26) at the beginning of the study, in comparison to “TNF−negative” alcoholics had greater plasma lipids concentration and greater platelets volume at the study start, and after 4 weeks and 6 months abstinence they had greater collagen induced platelets aggregation and lower total antioxidative plasma state. Conclusions. 1. In studied alcoholics TNF−α plasma concentration was the highest after alcohol withdrawal and decreased within abstinence period. 2. In TNF−positive alcoholics the unfavourable changes in cardiovascular event risk factors during following weeks of abstinence were more expressed, what suggests usefulness of TNF− α determination as a marker of unfavourable changes in atherosclerosis risk factors during anti−relapse therapy (Adv Clin Exp Med 2005, 14, 3, 511–521)." @default.
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- W2187474184 date "2005-01-01" @default.
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- W2187474184 title "Tumour Necrosis Factor−α and Its Relationships to the Biochemical Factors Potentially Involved in Atherosclerotic Processes in Alcohol Dependent Male Patients after Alcohol Withdrawal* Stężenie czynnika martwicy guza typu α oraz jego związek z poziomem czynników biochemicznych, potencjalnie związanych z rozwojem miażdżycy w okresie abstynencji u mężczyzn uzależnionych od alkoholu" @default.
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