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• W2187510189 abstract "Introduction: The current investigation aimed to study the efficacy of hemostatic therapy guided either by conventional coagulation analyses or point-of-care (POC) testing in coagulopathic cardiac surgery patients. Methods: Patients undergoing complex cardiac surgery were assessed for eligibility. Those patients in whom diffuse bleeding was diagnosed after heparin reversal or increased blood loss during the first 24 postoperative hours were enrolled and randomized to the conventional or POC group. Thromboelastometry and whole blood impedance aggregometry have been performed in the POC group. The primaryoutcomevariablewasthenumberoftransfusedunits of packed erythrocytes during the first 24 h after inclusion. Secondary outcome variables included postoperative blood loss, use and costs of hemostatic therapy, and clinical outcome parameters. Sample size analysis revealed a sample size of at least 100 patients per group. Results: There were 152 patients who were screened for eligibility and 100 patients were enrolled in the study. After randomization of 50 patients to each group, a planned interim analysis revealed a significant difference in erythrocyte transfusionrateintheconventionalcomparedwiththePOC group [5 (4;9) versus 3 (2;6) units [median (25 th and 75 th percentile)], P 0.001]. The study was terminated early. The secondary outcome parameters of fresh frozen plasma and platelet transfusion rates, postoperative mechanical ventilation time, length of intensive care unit stay, composite adverseeventsrate,costsofhemostatictherapy,and6-month mortality were lower in the POC group. Conclusions: Hemostatic therapy based on POC testing reduced patient exposure to allogenic blood products and provided significant benefits with respect to clinical outcomes." @default.
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• W2187510189 date "2012-01-01" @default.
• W2187510189 modified "2023-09-27" @default.
• W2187510189 title "A Prospective, Randomized Clinical Trial of Efficacy in Coagulopathic Cardiac Surgery Patients" @default.
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