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- W2187536146 abstract "Thesubependymalzone(SEZ)ofthelateralventriclesisoneoftheareasoftheadultbrainwherenewneuronsarecontinuouslygenerated fromneuralstemcells(NSCs),viarapidlydividingprecursors.Thisneurogenicnicheisacomplexcellularandextracellularmicroenvironment, highly vascularized compared to non-neurogenic periventricular areas, within which NSCs and precursors exhibit distinct behavior.Here,weinvestigatethepossiblemechanismsbywhichextracellularmatrixmoleculesandtheirreceptorsmightregulatethis differential behavior. We show that NSCs and precursors proceed through mitosis in the same domains within the SEZ of adult male mice—albeitwithNSCsnearerependymalcells—andthatdistancefromtheventricleisastrongerlimitingfactorforneurogenicactivity thandistancefrombloodvessels.Furthermore,weshowthatNSCsandprecursorsareembeddedinalaminin-richextracellularmatrix, towhichtheycanbothcontribute.Importantly,theyexpressdifferentiallevelsofextracellularmatrixreceptors,withNSCsexpressinglowlevels of61 integrin, syndecan-1, and lutheran, andin vivoblocking of1 integrin selectively induced the proliferation and ectopic migration of precursors.Finally,whenNSCsareactivatedtoreconstitutethenicheafterdepletionofprecursors,expressionoflamininreceptorsisupregulated. These results indicate that the distinct behavior of adult NSCs and precursors is not necessarily regulated via exposure to differential extracellularsignals,butratherviaintrinsicregulationoftheirinteractionwiththeirmicroenvironment." @default.
- W2187536146 created "2016-06-24" @default.
- W2187536146 creator A5026503004 @default.
- W2187536146 date "2010-01-01" @default.
- W2187536146 modified "2023-09-26" @default.
- W2187536146 title "QuiescenceandActivationofStemandPrecursorCell PopulationsintheSubependymalZoneoftheMammalian BrainAreAssociatedwithDistinctCellularandExtracellular MatrixSignals" @default.
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