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- W2187557766 abstract "pressure (Pdi) after right phrenic nerve stimulation at 1 Hz. Pdiwas measured before andduring aminophylline infusion (6mg/kgover 30 minutes), during whichtherapeutic concentrations oftheophylline were attained (mean 13.8mg/l, range 8.520.2). ThePdiachieved was notaffected byaminophylline. Thisresult suggeststhattheophylline attherapeutic concentrations haslittle effect on thecontractility ofthenormalhuman diaphragm. Methylxanthines arecommonlyusedto treat patients withairways obstruction andhaveabeneficial action inrelaxing airway smoothmuscle and stimulating thecentral nervous system.' Thesedrugs arealso knowntoactonskeletal muscle, producing appreciable potentiation oftwitch force invitro at millimolar concentrations.2 Ithasbeensuggested that aminophylline intherapeutic dosage mayalso reduce orreverse respiratory muscle fatigue.3 Muscle fatigue characterised byaselective reduction offorce inresponse tolowormoderate frequencies ofexcitation (less than30Hz)with preservation offorce athigher frequencies (50-100 Hz) develops inlimbmuscles withprolonged highwork loads.4 Thislow frequency fatigue reflects diminished twitch tension.5 Withsufficient ventilatory stress lowfrequency fatigue occurs inthe sternomastoid ofnormal subjects6 andpatients with airways obstruction7 andcanalsodevelop inthe humandiaphragm.89 Invitro studyofstrips of skeletal muscle hasshownthat highconcentrations ofxanthines potentiate twitch tension sufficiently to reverse lowfrequency fatigue, whereas concentrations closer totherapeutic levels havelittle effect.2 Several recent invitro animal studies, however, suggestthataminophylline attherapeutic concentrations mayimprove thecontractile function ofthe diaphragm.'0 '3Similarly, inmanaminophylline has beenreported toincrease diaphragm force andto protect thediaphragm fromdeveloping low frequency fatigue.3 Using asimilar protocol, however, wewereunable toshowabeneficial effect of Address forreprint requests: DrJohnMoxham, Chest Unit, Kings College Hospital, LondonSE59RS." @default.
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- W2187557766 date "1985-01-01" @default.
- W2187557766 modified "2023-09-24" @default.
- W2187557766 title "Effect ofaminophylline on thehumandiaphragm" @default.
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