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- W2187573997 abstract "� Tyrosinase is a common biological enzyme that produces the pigment melanin. Chalcones are molecules currently being researched as potential tyrosinase inhibitors. The purpose of this research project is to create new derivatives of chalcones by using two reaction methods and assay all compounds made; the second goal is to modify the procedures for the undergraduate lab course. The aldol condensation was the main reaction used under two methods: the standard synthesis using solvent and the solvent-free synthesis. Substituted acetophenones and benzaldehydes were reacted together with NaOH to synthesize chalcones with various arrangements of hydroxyl, methoxy, amino, fluoro and chloro substituents. Products of successful reactions were isolated, purified and characterized. A total of forty chalcones were synthesized. An enzyme assay will be done at a later date in order to determine the ability of the synthesized chalcones to inhibit tyrosinase." @default.
- W2187573997 created "2016-06-24" @default.
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- W2187573997 date "2009-01-01" @default.
- W2187573997 modified "2023-09-24" @default.
- W2187573997 title "Synthesis of Tyrosinase Inhibitors: Designing Chalcones" @default.
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