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- W2187585605 abstract "Background: The FAS/FASLG system shows a key role in regulating apoptosis. Objectives: Previous findings have indicated that a significantly increased risk of vitiligo was associated with FAS-1377 AA genotype and the FAS-1377 AG genotype when compared with FAS1377 GG genotype in Chinese population. Material and Methods: We investigated the FAS-670, FAS-1377, FAS-844 and FAS-124 polymorphisms in 113 vitiligo patients and also compared 196 controls. Results: We found that a significantly increased vitiligo was associated with the FAS-670 GA genotype [adjusted odds ratio (OR), 2.87; 95% confidence interval (CI), 1.37-6.03] when compared with the controls. However, there were no evident risk associated with FAS-1377, 844 and 124 genotypes. Conclusion: This is the first report of an association between FAS-670, FAS-1377, FAS-844 and FAS124 gene polymorphism and vitiligo in a Turkish population. The results of this study suggest that the presence of FAS-670 GA genotype can be regarded as risk factor for vitiligo, and especially for vitiligo in Turkish population." @default.
- W2187585605 created "2016-06-24" @default.
- W2187585605 date "2014-01-01" @default.
- W2187585605 modified "2023-09-26" @default.
- W2187585605 title "Association of FAS Gene Promoter Functional Polymorphisms and the Risk of Vitiligo in Turkish Populations" @default.
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- W2187585605 doi "https://doi.org/10.6003/jtad.1483a1" @default.
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