Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187598786> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2187598786 endingPage "245" @default.
- W2187598786 startingPage "239" @default.
- W2187598786 abstract "Laryngeal squamous cell carcinoma (LSCC) is a frequent malignancy with a complex and undefined etiology to date. The recently identified cyclin-dependent kinase inhibitor p15INK4b is frequently deleted in human tumors. Previous evidence has pointed to a related gene, p16INK4a, as another target for deletion. Both genes express cyclin D inhibitor proteins. To determine the importance of cell cycle regulators in LSCC relative to more traditional surgical and pathological prognostic factors, p15INK4b, p16INK4a and cyclin D1 analyses were performed. Forty-one malignant tumor tissues and 20 minimal pathological lesions (MPL) of the larynx were examined for deletion of the p16INK4a and p15INK4b genes using polymerase chain reaction. Cyclin D1 expression was studied by Western blotting. Deletions of p16INK4a and p15INK4b were observed in 48.8 % and 51.2% of LSCC patients, respectively. Meanwhile, no deletion was observed in MPL (p<0.001). Cyclin D1 was expressed in 43.9% of patients with LSCC versus 30% with MPL (p=0.29). Although the frequency of p16INK4a and p15INK4b deletions were higher in advanced than early tumor stages, the difference was statistically insignificant. Ninety percent of patients with deletion of p16INK4a had deletion of the p15INK4b gene. Both cyclin D1 expression and deletion of p15INK4b were found to be independent prognotic predictors of disease recurrence. p16INK4a and p15INK4b gene deletions are exclusively related to malignancy of the larynx. Cyclin D1 expression and p15INK4b gene deletion are potential prognostic indicators of recurrence of LSCC." @default.
- W2187598786 created "2016-06-24" @default.
- W2187598786 creator A5021362095 @default.
- W2187598786 creator A5039362444 @default.
- W2187598786 creator A5086697904 @default.
- W2187598786 creator A5091269607 @default.
- W2187598786 date "2005-07-01" @default.
- W2187598786 modified "2023-10-14" @default.
- W2187598786 title "The Cell Cycle Regulators P16INK4a, P15INK4b and Cyclin D1: Relationship to Clinicopathological Parameters and Disease-free Survival in Laryngeal Carcinoma Patients." @default.
- W2187598786 cites W1492085907 @default.
- W2187598786 cites W1499660750 @default.
- W2187598786 cites W1560121420 @default.
- W2187598786 cites W1562403836 @default.
- W2187598786 cites W1579641819 @default.
- W2187598786 cites W1593523253 @default.
- W2187598786 cites W1979300931 @default.
- W2187598786 cites W1990858972 @default.
- W2187598786 cites W1995986482 @default.
- W2187598786 cites W1997022552 @default.
- W2187598786 cites W1997073961 @default.
- W2187598786 cites W2010493387 @default.
- W2187598786 cites W2022607781 @default.
- W2187598786 cites W2031610022 @default.
- W2187598786 cites W2032062839 @default.
- W2187598786 cites W2043051850 @default.
- W2187598786 cites W2045518196 @default.
- W2187598786 cites W2047586429 @default.
- W2187598786 cites W2055238483 @default.
- W2187598786 cites W2064937786 @default.
- W2187598786 cites W2076006588 @default.
- W2187598786 cites W2077218089 @default.
- W2187598786 cites W2077620804 @default.
- W2187598786 cites W2090280374 @default.
- W2187598786 cites W2110513711 @default.
- W2187598786 cites W2128635872 @default.
- W2187598786 cites W2136883754 @default.
- W2187598786 cites W2151572701 @default.
- W2187598786 cites W2165404200 @default.
- W2187598786 cites W2417369467 @default.
- W2187598786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31394712" @default.
- W2187598786 hasPublicationYear "2005" @default.
- W2187598786 type Work @default.
- W2187598786 sameAs 2187598786 @default.
- W2187598786 citedByCount "0" @default.
- W2187598786 crossrefType "journal-article" @default.
- W2187598786 hasAuthorship W2187598786A5021362095 @default.
- W2187598786 hasAuthorship W2187598786A5039362444 @default.
- W2187598786 hasAuthorship W2187598786A5086697904 @default.
- W2187598786 hasAuthorship W2187598786A5091269607 @default.
- W2187598786 hasConcept C104317684 @default.
- W2187598786 hasConcept C120089663 @default.
- W2187598786 hasConcept C199835354 @default.
- W2187598786 hasConcept C2777546739 @default.
- W2187598786 hasConcept C2779399171 @default.
- W2187598786 hasConcept C2780360765 @default.
- W2187598786 hasConcept C29537977 @default.
- W2187598786 hasConcept C502942594 @default.
- W2187598786 hasConcept C54355233 @default.
- W2187598786 hasConcept C86803240 @default.
- W2187598786 hasConceptScore W2187598786C104317684 @default.
- W2187598786 hasConceptScore W2187598786C120089663 @default.
- W2187598786 hasConceptScore W2187598786C199835354 @default.
- W2187598786 hasConceptScore W2187598786C2777546739 @default.
- W2187598786 hasConceptScore W2187598786C2779399171 @default.
- W2187598786 hasConceptScore W2187598786C2780360765 @default.
- W2187598786 hasConceptScore W2187598786C29537977 @default.
- W2187598786 hasConceptScore W2187598786C502942594 @default.
- W2187598786 hasConceptScore W2187598786C54355233 @default.
- W2187598786 hasConceptScore W2187598786C86803240 @default.
- W2187598786 hasIssue "4" @default.
- W2187598786 hasLocation W21875987861 @default.
- W2187598786 hasOpenAccess W2187598786 @default.
- W2187598786 hasPrimaryLocation W21875987861 @default.
- W2187598786 hasRelatedWork W1978939273 @default.
- W2187598786 hasRelatedWork W1993083676 @default.
- W2187598786 hasRelatedWork W1994579188 @default.
- W2187598786 hasRelatedWork W2063780942 @default.
- W2187598786 hasRelatedWork W2099645146 @default.
- W2187598786 hasRelatedWork W2128955496 @default.
- W2187598786 hasRelatedWork W2413931230 @default.
- W2187598786 hasRelatedWork W2789271127 @default.
- W2187598786 hasRelatedWork W2889145277 @default.
- W2187598786 hasRelatedWork W3105553956 @default.
- W2187598786 hasVolume "2" @default.
- W2187598786 isParatext "false" @default.
- W2187598786 isRetracted "false" @default.
- W2187598786 magId "2187598786" @default.
- W2187598786 workType "article" @default.