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- W2187613046 abstract "Equine athletes suffer severe breakdown injuries during racing that, although infrequent, can have tragic results. A critical factor in treating horses immediately after a breakdown injury is the difficulty in calming an excited, stressed, exhausted, and potentially physically challenged (nonweight bearing on a limb or limbs) horse. This difficulty may prevent the safe removal of the horse from the racetrack and predispose the horse to further injury. An concomitant concern is the potential for prolonging the recuperative period from exercise in the injured horse. Recuperation in the horse is delayed if horses are made to stand stationary, as would be the case with injury.1 Cardiac output and mean right atrial pressure are higher and peripheral vascular resistance is lower in horses that walk compared with horses that stand stationary during recuperation from maximal exercise. These changes result in a delay in the return of blood lactate and venous bicarbonate concentrations to pre-exercise levels. Additional decreases in cardiac output, such as those that would be anticipated following the administration of sedatives and tranquilizers, might further retard the rate of recuperation. The behavioral, cardiovascular, and respiratory effects that result from the administration of sedatives and tranquilizers to horses at rest have been investigated.2–7 We could find no reports describing the effects of sedatives and tranquilizers administered during recuperation from maximal exercise. This project was designed to determine the intravenous dose of xylazine, detomidine, and a combination of xylazine and acepromazine that is required to produce effective sedation in horses immediately after maximal exercise." @default.
- W2187613046 created "2016-06-24" @default.
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- W2187613046 date "1997-01-01" @default.
- W2187613046 modified "2023-09-27" @default.
- W2187613046 title "Sedative Administration to Horses Immediately After Maximal Exercise: Determination of Drug and Dose" @default.
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