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• W2187613426 endingPage "52" @default.
• W2187613426 startingPage "17" @default.
• W2187613426 abstract "The three members of the human ras family of proto-oncogenes (H-ras, K-ras, and N-ras) encode highly related, low-mol-wt (21 kDa), guanine nucleotide (GDP and GTP) binding proteins that are located at the inner face of the plasma membrane (Barbacid, 1987). The Ras proteins are believed to function as molecular switches that regulate the passage of mitogenic signals from growth factor receptors to the nucleus via signal transduction pathways involved in cell proliferation (Bourne et al., 1990a,b; Egan and Weinberg, 1993). The Ras proteins perform this activity by a regulated GDP/GTP cycle, much in the manner of the well-characterized heterotrimeric G proteins, that involves their shuttling between inactive, GDP-bound and active, GTP-bound states (Gilman, 1984). Thus, an appropriate mitogenic signal causes a transient increase in the level of GTP-bound Ras, which then associates with an as yet unidentified downstream effector target to mediate the passage of the signal before being rapidly returned to the inactive, GDP-bound form, thereby terminating the mitogenic response (Satoh et al., 1992). Oncogenic mutations cause a deregulation of the GDP/GTP cycle, lock the protein in the active, GTP-bound state, and consequently result in the constitutive activation of Ras-mediated stimulation of cellular proliferation.KeywordsThyroid Medullary CarcinomaHuman MalignancyPituitary CarcinomaMitogenic PathwayLung Large Cell CarcinomaThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W2187613426 created "2016-06-24" @default.
• W2187613426 creator A5001222215 @default.
• W2187613426 creator A5064063895 @default.
• W2187613426 date "1995-01-01" @default.
• W2187613426 modified "2023-09-27" @default.
• W2187613426 title "ras Proto-Oncogene Activation in Human Malignancy" @default.
• W2187613426 cites W143471271 @default.
• W2187613426 cites W1480125182 @default.
• W2187613426 cites W1490333589 @default.
• W2187613426 cites W1510833310 @default.
• W2187613426 cites W1557478309 @default.
• W2187613426 cites W1563951590 @default.
• W2187613426 cites W1583035638 @default.
• W2187613426 cites W158810188 @default.
• W2187613426 cites W1605252096 @default.
• W2187613426 cites W1605851497 @default.
• W2187613426 cites W1679229316 @default.
• W2187613426 cites W1757437769 @default.
• W2187613426 cites W1808352992 @default.
• W2187613426 cites W1891870429 @default.
• W2187613426 cites W1921782937 @default.
• W2187613426 cites W1924198160 @default.
• W2187613426 cites W1945654446 @default.
• W2187613426 cites W1963633445 @default.
• W2187613426 cites W1965444989 @default.
• W2187613426 cites W1965846351 @default.
• W2187613426 cites W1966683022 @default.
• W2187613426 cites W1966794775 @default.
• W2187613426 cites W1967452306 @default.
• W2187613426 cites W1967882942 @default.
• W2187613426 cites W1968362237 @default.
• W2187613426 cites W1970030465 @default.
• W2187613426 cites W1971377120 @default.
• W2187613426 cites W1971475788 @default.
• W2187613426 cites W1971602793 @default.
• W2187613426 cites W1972011712 @default.
• W2187613426 cites W1973677994 @default.
• W2187613426 cites W1973800266 @default.
• W2187613426 cites W1974513412 @default.
• W2187613426 cites W1974997269 @default.
• W2187613426 cites W1975315379 @default.
• W2187613426 cites W1975922147 @default.
• W2187613426 cites W1977302628 @default.
• W2187613426 cites W1977317709 @default.
• W2187613426 cites W1977598234 @default.
• W2187613426 cites W1978274173 @default.
• W2187613426 cites W1978580469 @default.
• W2187613426 cites W1978798502 @default.
• W2187613426 cites W1979027806 @default.
• W2187613426 cites W1979257234 @default.
• W2187613426 cites W1979527189 @default.
• W2187613426 cites W1979646488 @default.
• W2187613426 cites W1980022529 @default.
• W2187613426 cites W1980307845 @default.
• W2187613426 cites W1981389934 @default.
• W2187613426 cites W1981634986 @default.
• W2187613426 cites W1981655068 @default.
• W2187613426 cites W1982838213 @default.
• W2187613426 cites W1982933055 @default.
• W2187613426 cites W1985417906 @default.
• W2187613426 cites W1985977960 @default.
• W2187613426 cites W1986383101 @default.
• W2187613426 cites W1986409528 @default.
• W2187613426 cites W1986758681 @default.
• W2187613426 cites W1988051356 @default.
• W2187613426 cites W1989009382 @default.
• W2187613426 cites W1989205333 @default.
• W2187613426 cites W1990513983 @default.
• W2187613426 cites W1991142036 @default.
• W2187613426 cites W1992972153 @default.
• W2187613426 cites W1993418815 @default.
• W2187613426 cites W1994139415 @default.
• W2187613426 cites W1994305152 @default.
• W2187613426 cites W1995134833 @default.
• W2187613426 cites W1995259219 @default.
• W2187613426 cites W1997537717 @default.
• W2187613426 cites W1998392339 @default.
• W2187613426 cites W1998759761 @default.
• W2187613426 cites W1998998600 @default.
• W2187613426 cites W1999157780 @default.
• W2187613426 cites W1999803187 @default.
• W2187613426 cites W1999824494 @default.
• W2187613426 cites W2000072353 @default.
• W2187613426 cites W2000269495 @default.
• W2187613426 cites W2003267467 @default.
• W2187613426 cites W2005189737 @default.
• W2187613426 cites W2005529016 @default.
• W2187613426 cites W2008800308 @default.
• W2187613426 cites W2009338295 @default.
• W2187613426 cites W2009348383 @default.
• W2187613426 cites W2009484032 @default.
• W2187613426 cites W2010002962 @default.
• W2187613426 cites W2010488494 @default.
• W2187613426 cites W2011751979 @default.
• W2187613426 cites W2012558239 @default.
• W2187613426 cites W2012806962 @default.
• W2187613426 cites W2013585351 @default.

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