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- W2187619345 abstract "The acidic food vacuole of Plasmodium falciparum has been the subject of intense scientific investigation in the 40 years since its role in the digestion of host hemoglobin was first suggested. This proposed role has important implications for the complex host-parasite inter-relationship and also for the mode of action of several of the most effective antimalarial drugs. In addition, adaptive changes in the physiology of this organelle are implicated in drug resistance. Here we show that in addition to these functions, the digestive food vacuole of the malaria parasite is a dynamic internal store for free Ca 2 , a role hitherto unsuspected. With the aid of live-cell laser scanning confocal imaging, spatiotemporal studies revealed that maintenance of elevated free Ca 2 in the digestive food vacuole (relative to cytosolic levels) is achieved by a thapsigargin (and cyclopiazonic acid)-sensitive Ca 2 -pump in cooperation with a H-dependent Ca 2 transporter. Redistribution of free cytosolic and vacuolar Ca 2 during parasite growth also suggests that vacuolar Ca 2 plays an essential role in parasite morphogenesis. These data imply that the digestive food vacuole of the malaria parasite is functionally akin to the vacuole of plants (tonoplast) and the small electron-dense granules of some parasites (acidocalcisomes) whereby H-coupled Ca 2 transport is involved in ion transport, Ca 2 homeostasis, and signal" @default.
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- W2187619345 date "2003-01-01" @default.
- W2187619345 modified "2023-09-27" @default.
- W2187619345 title "The Digestive Food Vacuole of the Malaria Parasite Is a Dynamic" @default.
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