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- W2187620713 abstract "Tumor heterogeneity has warranted the development and validation of gene expression signatures. This approach will help the oncologist in improving diagnosis and/or prognosis. Chronic Inflammation is considered to be involved in neoplasia and commonalities have been observed, in the wound healing response as well as in tumorigenesis. In this regard, the serum response of fibroblasts was shown to mimic the in vivo wound healing response in terms of the “wound response signature” using a variety of molecular biological approaches. Correlation of such signatures, using samples obtained by ex vivo and in vitro methods, developed and/or validated by a variety of genomic, transcriptomic and proteomic approaches with the clinical outcome, will enable the researcher and the oncologist/ clinician to interface and potentially develop and validate cost-effective methods of diagnosis potentially leading up to personalized therapy. Patient selection and stratification and sample size considerations are paramount in developing and validation of improved genomic classifiers." @default.
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- W2187620713 date "2007-03-01" @default.
- W2187620713 modified "2023-09-27" @default.
- W2187620713 title "Gene Expression Signatures –Ex Vivo/In VitroApproaches for Signature Development and Validation" @default.
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- W2187620713 doi "https://doi.org/10.1080/09723757.2007.11885989" @default.
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