Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187620959> ?p ?o ?g. }
- W2187620959 endingPage "G890" @default.
- W2187620959 startingPage "G883" @default.
- W2187620959 abstract "Hemodynamic changes in cirrhosis may be associated with alterations in aortic vascular smooth muscle cell (AVSMC) function. The present study compared the proliferative response to serum and growth factors in cirrhotic and control AVSMC. Serum from cirrhotic rats, cirrhotic cell lysates, and the conditioned medium of cultured cirrhotic AVSMC induced an increase in [ 3 H]thymidine incorporation in control but not in cirrhotic AVSMC. Platelet-derived growth factor-β (PDGF-BB) induced a greater increase in [ 3 H]thymidine incorporation in cirrhotic than in control cells. [ 3 H]thymidine incorporation induced by cirrhotic conditioned medium was blocked by anti-PDGF antibody. Immunoblot studies showed that the anti-PDGF antibody recognized a 30-kDa protein in the conditioned medium of cirrhotic AVSMC culture, a protein corresponding to PDGF. Binding studies of PDGF-BB indicated a twofold increase in receptor density in cirrhotic AVSMC with no alteration in affinity for PDGF-BB. We conclude that an increased responsiveness of cirrhotic AVSMC to the PDGF could contribute to alterations in AVSMC and muscle cell tone that may play a role in the hemodynamic changes in cirrhosis." @default.
- W2187620959 created "2016-06-24" @default.
- W2187620959 creator A5014056253 @default.
- W2187620959 creator A5015163049 @default.
- W2187620959 creator A5063708195 @default.
- W2187620959 creator A5088338447 @default.
- W2187620959 date "1997-10-01" @default.
- W2187620959 modified "2023-09-25" @default.
- W2187620959 title "Responsiveness to growth factors in aortic vascular smooth muscle cells from rats with cirrhosis" @default.
- W2187620959 cites W1482652685 @default.
- W2187620959 cites W1490171983 @default.
- W2187620959 cites W1512165930 @default.
- W2187620959 cites W1563405664 @default.
- W2187620959 cites W1945199177 @default.
- W2187620959 cites W1965526093 @default.
- W2187620959 cites W1982675479 @default.
- W2187620959 cites W1984599257 @default.
- W2187620959 cites W1986868198 @default.
- W2187620959 cites W1989883100 @default.
- W2187620959 cites W1990132316 @default.
- W2187620959 cites W1991074555 @default.
- W2187620959 cites W1997582444 @default.
- W2187620959 cites W1999182913 @default.
- W2187620959 cites W2009416998 @default.
- W2187620959 cites W2038300967 @default.
- W2187620959 cites W2044510333 @default.
- W2187620959 cites W2048249544 @default.
- W2187620959 cites W2049596719 @default.
- W2187620959 cites W2056966654 @default.
- W2187620959 cites W2059618963 @default.
- W2187620959 cites W2066875325 @default.
- W2187620959 cites W2091947319 @default.
- W2187620959 cites W2100837269 @default.
- W2187620959 cites W2123066945 @default.
- W2187620959 cites W2126590643 @default.
- W2187620959 cites W2128614663 @default.
- W2187620959 cites W2128781299 @default.
- W2187620959 cites W2148371225 @default.
- W2187620959 cites W2151178976 @default.
- W2187620959 cites W2155815716 @default.
- W2187620959 cites W2156807957 @default.
- W2187620959 cites W2418978545 @default.
- W2187620959 cites W2917574383 @default.
- W2187620959 cites W4293247451 @default.
- W2187620959 doi "https://doi.org/10.1152/ajpgi.1997.273.4.g883" @default.
- W2187620959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9357831" @default.
- W2187620959 hasPublicationYear "1997" @default.
- W2187620959 type Work @default.
- W2187620959 sameAs 2187620959 @default.
- W2187620959 citedByCount "1" @default.
- W2187620959 crossrefType "journal-article" @default.
- W2187620959 hasAuthorship W2187620959A5014056253 @default.
- W2187620959 hasAuthorship W2187620959A5015163049 @default.
- W2187620959 hasAuthorship W2187620959A5063708195 @default.
- W2187620959 hasAuthorship W2187620959A5088338447 @default.
- W2187620959 hasBestOaLocation W21876209591 @default.
- W2187620959 hasConcept C126322002 @default.
- W2187620959 hasConcept C134018914 @default.
- W2187620959 hasConcept C159654299 @default.
- W2187620959 hasConcept C170493617 @default.
- W2187620959 hasConcept C180361614 @default.
- W2187620959 hasConcept C203014093 @default.
- W2187620959 hasConcept C2775960820 @default.
- W2187620959 hasConcept C2777214474 @default.
- W2187620959 hasConcept C2779395532 @default.
- W2187620959 hasConcept C2781294074 @default.
- W2187620959 hasConcept C2992686903 @default.
- W2187620959 hasConcept C55493867 @default.
- W2187620959 hasConcept C62112901 @default.
- W2187620959 hasConcept C71924100 @default.
- W2187620959 hasConcept C86803240 @default.
- W2187620959 hasConceptScore W2187620959C126322002 @default.
- W2187620959 hasConceptScore W2187620959C134018914 @default.
- W2187620959 hasConceptScore W2187620959C159654299 @default.
- W2187620959 hasConceptScore W2187620959C170493617 @default.
- W2187620959 hasConceptScore W2187620959C180361614 @default.
- W2187620959 hasConceptScore W2187620959C203014093 @default.
- W2187620959 hasConceptScore W2187620959C2775960820 @default.
- W2187620959 hasConceptScore W2187620959C2777214474 @default.
- W2187620959 hasConceptScore W2187620959C2779395532 @default.
- W2187620959 hasConceptScore W2187620959C2781294074 @default.
- W2187620959 hasConceptScore W2187620959C2992686903 @default.
- W2187620959 hasConceptScore W2187620959C55493867 @default.
- W2187620959 hasConceptScore W2187620959C62112901 @default.
- W2187620959 hasConceptScore W2187620959C71924100 @default.
- W2187620959 hasConceptScore W2187620959C86803240 @default.
- W2187620959 hasIssue "4" @default.
- W2187620959 hasLocation W21876209591 @default.
- W2187620959 hasLocation W21876209592 @default.
- W2187620959 hasOpenAccess W2187620959 @default.
- W2187620959 hasPrimaryLocation W21876209591 @default.
- W2187620959 hasRelatedWork W1993367266 @default.
- W2187620959 hasRelatedWork W2000951003 @default.
- W2187620959 hasRelatedWork W2033166621 @default.
- W2187620959 hasRelatedWork W2049535510 @default.
- W2187620959 hasRelatedWork W2357330868 @default.
- W2187620959 hasRelatedWork W2360893882 @default.
- W2187620959 hasRelatedWork W2369516964 @default.