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- W2187622422 abstract "C-reactive protein (CRP), anacute-phase reactant whichbinds tophosphocholine (PC)inthepneumococcal cell wall, andanti-PC antibodies areprotective against experimental pneumococcal bacteremia inmice.To determine therelative opsonic capacities ofCRP andanti-PC compared withthoseofantibodies against pneumococcal capsular polysaccharides (anti-PCP), wecorrelated invitro opsonic activity forserotype 7F Streptococcus pneumoniae withconcentrations ofCRP,anti-PC, andanti-type 7FPCPinhumanserafrom10 normalsubjects and38patients withsickle cell (SS) disease, ahigh-risk groupforpneumococcal infection. Opsonic activity, measured byaradiolabeled bacterial uptake assay, correlated withanti-PCP levels butnot withCRPoranti-PC inboththenormal subjects andpatients withSSdisease. Addition ofCRPtonormalsera didnotincrease opsonic activity forserotypes 4and7FS.pneumoniae, although itdidsoforserotype 27,a nonpathogenic strain unique forhaving PCinitscapsule. CRPandanti-PC werenoteffective opsonins when theyboundtothepneumococcal cell wallrather thanthecapsule. Theprotective effects ofCRPoranti-PC against these serotypes maybeproduced bymeansother thancomplement-dependent opsonization." @default.
- W2187622422 created "2016-06-24" @default.
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- W2187622422 date "1985-01-01" @default.
- W2187622422 modified "2023-09-27" @default.
- W2187622422 title "Correlation ofSerumOpsonins withInVitro Phagocytosis of Streptococcus pneumoniae" @default.
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