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- W2187623986 abstract "Background: Telomerase is a ribonucleoprotein, which adds telomeric repeats onto the 3’ end of existing telomers at the end of chromosomes in eukaryotes. One hypothesis states that telomere length may function as a mitotic clock, therefore expression of telomerase activity in cancer cells may be a necessary and essential step for tumor development and progression. Methods: The detectability of telomerase activity in chicken embryo fibroblast (CEF) cells infected with different passages of Marek's disease virus (MDV) was tested with the TRAPEZE ® telomerase detection kit at passages 14 (P14), P80/1 and P120 for the Woodland strain, and passage 9 (P9) for the MPF57 strain. Results: The results showed increased telomerase activity in MDV Woodlands strain at P14 and MPF57 strain at P9. Conclusion: Our results suggest that MDV-transformed cells at low passage are a suitable system for the study of telomerases in tumor development and for testing telomerase-inhibiting drugs." @default.
- W2187623986 created "2016-06-24" @default.
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- W2187623986 date "2010-01-01" @default.
- W2187623986 modified "2023-09-27" @default.
- W2187623986 title "Archive of SID Telomerase Activity in Chicken Embryo Fibroblast Cell Cultures Infected with Marek's Disease Virus" @default.
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