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- W2187663078 abstract "Background: Barrett’s Esophagus (BE) is a complication of gastroesophageal reflux disease (GERD) and can be a premalignant condition. Nevertheless, there is no consensus about the effectiveness of surgery in preventing malignant transformation in patients with BE. The impact of Laparoscopic Anti-Reflux Surgery (LARS) on those suffering from BE is still not understood. The objective of this study is to prospectively evaluate clinical, endoscopic and histopathological results after LARS in patients with BE. Methods: 372 patients suffering from GERD underwent Laparoscopic Nissen Fundoplication (LapNissen). Among them, 95 (25.5%) presented BE. Follow-up using endoscopic biopsy was performed in all patients. The average follow-up was 59.8 months. Results: The control of symptoms was effective in 92 patients. Three patients remained symptomatic, and BE remained unaltered in these patients. Regression of BE occurred in 58 patients (63.9%). Of these, 26 (28.9%) showed no further signs of BE in endoscopic or histopathological examinations. In one patient, who remained asymptomatic after surgery, the degree of dysplasia increased to high-grade dysplasia, and another asymptomatic patient developed adenocarcinoma. Both underwent endoscopic mucosectomy of the BE area. Conclusions: LapNissen is safe and effective in the control of symptoms in a significant number of patients with BE. In spite of the control of GERD attained by most patients and regression occurring in a high percentage of the patients who underwent LARS, the development of high-grade dysplasia and adenocarcinoma is not fully prevented by anti-reflux surgery. Routine endoscopy follow-up with biopsy is recommended for all patients with BE after LARS." @default.
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- W2187663078 date "2011-01-01" @default.
- W2187663078 modified "2023-10-18" @default.
- W2187663078 title "Laparoscopic Anti-Reflux Surgery Promotes Regression or Disappearance of Barrett's Esophagus, but does not Eliminate the Risk of Esophageal Adenocarcinoma Cirurgia Anti-Refluxo Promove a Regressão ou Desaparecimento do Esôfago de Barrett, mas não Elimina o Risco de Adenocarcinoma de Esôfago" @default.
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