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• W2187664404 abstract "JC virus (JCV) is a polyomavirus that causes progressive multifocal leukoencephalopathy (PML) in humans and is highly oncogenic in experimental animals. Transgenic mice with JCV T-antigen develop cerebellar tumors, which resemble human medulloblastomas, containing two distinct cell subpopulations, T-antigen positive and negative. In T-negative clones, a novel mutant p53 was detected (p53(mt)).We have compared p53(mt) to wild-type p53 (p53wt) in p53-null cells.p53(mt) had lost the transcriptional transactivation activity of p53(wt), and unlike p53(wt), partially localized to the cytoplasm. Unlike mutant p53 from many human cancers, p53(mt) did not show a gain of function or a dominant negative phenotype. Adenovirus expressing p53(wt) but not p53(mt) inhibited cell growth and induced apoptosis of p53-null cells.During the course of tumor evolution of the JCV T-antigen mouse medulloblastoma, a mutation occurred that inactivated p53 allowing tumor progression even in the absence of continued T-antigen expression." @default.
• W2187664404 created "2016-06-24" @default.
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• W2187664404 date "2007-01-05" @default.
• W2187664404 modified "2023-09-23" @default.
• W2187664404 title "Analysis of a mutant p53 protein arising in a medulloblastoma from a mouse transgenic for the JC virus early region." @default.
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• W2187664404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17201119" @default.
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