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- W2187715826 abstract "Glycosphingolipidsareamphipathicmoleculesconsistingofahydrophiliccarbohydratemoietyandlipophilicceramides(1).They are expressed mainly on the cell membrane and havevariousrolesincell-cellorcell-extracellularmatrixrecognitionandintheregulationofsignalingevents(2).Althoughcarbo-hydratestructuresontheglycosphingolipidsaswellasthoseonglycoproteinsareenormouslydiverse,theyareusuallychar-acteristic of different stages of development, a distinct celllineage,andvariousstepsofmalignanttransformation(3).Thesecelltype-specificprofilesofglycolipidcomponentsaredeterminedbyacombinationoftheglycosylationmachiner-ies expressed in individual tissues and cells (4). However,littleisknownaboutthemechanismsregulatingglycosyla-tionsystems(5).Studiesoftheregulationofcarbohydratesynthesisandex-pressionhavebeenhamperedbythelackofclonedglycosyl-transferasegenes.However,theisolationofcDNAsofthesegenes(6)hasimprovedtheunderstandingofthegenomicor-ganizationandthecontrolofthecelltype-specificexpressionofglycosyltransferases.Thestructureandtissue-specificexpres-sionoftheb-galactosidea2,6-sialyltransferase(7–10)andb1,4-galactosyltransferase(11–13)geneshavebeenanalyzed.How-ever, the enzymes encoded by these two genes catalyze thesynthesisofcarbohydratechainsonvariousglycoproteins,andtheglycosyltransferasegenesthataremainlyresponsibleforthesynthesisofglycosphingolipidshavenotbeenstudied.The level of b1,4-" @default.
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- W2187715826 date "1996-01-01" @default.
- W2187715826 modified "2023-09-24" @default.
- W2187715826 title "Genomic Organization and Chromosomal Assignment of the Human b1,4-N-Acetylgalactosaminyltransferase Gene" @default.
- W2187715826 cites W1900380445 @default.
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