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- W2187733137 abstract "The L-type calcium current (ICa-L) was studied in single ferret ventricular myocytes using whole-cell recording with single patch pipettes. Voltage-clamp experiments were performed at room temperature with internal and external Na(+)- and K(+)-free Tyrode solutions in order to isolate ICa-L. For depolarizing steps eliciting small ICa-L the decay of the current is best described by one exponential. For depolarizing steps eliciting large ICa-L (i.e. between -10 and +30 mV), the decay of the current is best described by the sum of two exponentials with a calcium-dependent fast (Tf) time constant and a voltage-dependent slow (Ts) time constant. Experiments conducted with different external concentration of Ca2+ and Ba2+ suggested that the inactivation and the time course of reactivation of the current after a depolarizing pulse are dependent on calcium ions. This confirms previous observations in heart muscle and reveals the existence of a calcium-dependent regulation process of the L-type calcium current in enzymatically dissociated ventricular myocytes from ferret heart." @default.
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- W2187733137 date "1993-02-01" @default.
- W2187733137 modified "2023-09-25" @default.
- W2187733137 title "Kinetic analysis of the L-type calcium current in enzymatically dissociated ferret ventricular myocytes." @default.
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