Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187736685> ?p ?o ?g. }
- W2187736685 abstract "Tumor cell motility is the hallmark of invasion and an essential step in metastasis. Cellular changes that occur during the progression of cancer affect proteins that drive actin dynamics; these changes modulate cell cycle progression and lead to more invasive cancers. Actin depolymerizing factor (ADF)/cofilins (actin dynamizing proteins) and their regulatory proteins are involved in the initiation of early steps in cell motility. ADF/cofilins play important roles in various stages of cancer progression including cell polarization and polarized migration, escape from apoptosis, and secretion of metalloproteases, all of which are important in metastasis. Vertebrates express ADF, cofilin-1 and cofilin-2, and even though ADF and cofilin have many qualitatively similar biochemical properties, they differ quantitatively in actin interaction and in some types of regulation and, thus, are not functionally identical. This review compares the activities of these two proteins with respect to how they may function during tumor cell invasion. Understanding the molecular pathways of tumor invasion will provide new diagnostic approaches and targets for the treatment of metastatic cancer. ﺮﺒﺘﻌﺗ" @default.
- W2187736685 created "2016-06-24" @default.
- W2187736685 creator A5057882929 @default.
- W2187736685 creator A5088598466 @default.
- W2187736685 date "2011-01-01" @default.
- W2187736685 modified "2023-09-28" @default.
- W2187736685 title "Redundant and Non-Redundant Functions of Actin Depolymerizing Factor (ADF) and Cofilin in Metastasis- Review" @default.
- W2187736685 cites W1499206140 @default.
- W2187736685 cites W1527650585 @default.
- W2187736685 cites W1542673196 @default.
- W2187736685 cites W1544613268 @default.
- W2187736685 cites W1554454384 @default.
- W2187736685 cites W1578172800 @default.
- W2187736685 cites W1658644371 @default.
- W2187736685 cites W1756291035 @default.
- W2187736685 cites W1863429598 @default.
- W2187736685 cites W193886648 @default.
- W2187736685 cites W1963721564 @default.
- W2187736685 cites W1964770292 @default.
- W2187736685 cites W1965921851 @default.
- W2187736685 cites W1967975220 @default.
- W2187736685 cites W1968309496 @default.
- W2187736685 cites W1968826282 @default.
- W2187736685 cites W1970072446 @default.
- W2187736685 cites W1970092562 @default.
- W2187736685 cites W1972779128 @default.
- W2187736685 cites W1975244918 @default.
- W2187736685 cites W1976100793 @default.
- W2187736685 cites W1976295685 @default.
- W2187736685 cites W1981954655 @default.
- W2187736685 cites W1984559046 @default.
- W2187736685 cites W1984803777 @default.
- W2187736685 cites W1987034229 @default.
- W2187736685 cites W1989642116 @default.
- W2187736685 cites W1991969047 @default.
- W2187736685 cites W1992825194 @default.
- W2187736685 cites W1993016783 @default.
- W2187736685 cites W1994844322 @default.
- W2187736685 cites W1995153837 @default.
- W2187736685 cites W1995517865 @default.
- W2187736685 cites W1996583326 @default.
- W2187736685 cites W1998102655 @default.
- W2187736685 cites W1998318188 @default.
- W2187736685 cites W1999920891 @default.
- W2187736685 cites W2001043279 @default.
- W2187736685 cites W2002003879 @default.
- W2187736685 cites W2003173961 @default.
- W2187736685 cites W2009606782 @default.
- W2187736685 cites W2016450222 @default.
- W2187736685 cites W2017562104 @default.
- W2187736685 cites W2019831558 @default.
- W2187736685 cites W2024527293 @default.
- W2187736685 cites W2026024603 @default.
- W2187736685 cites W2026648786 @default.
- W2187736685 cites W2031429450 @default.
- W2187736685 cites W2033657475 @default.
- W2187736685 cites W2033989449 @default.
- W2187736685 cites W2034408995 @default.
- W2187736685 cites W2042945898 @default.
- W2187736685 cites W2044419701 @default.
- W2187736685 cites W2045696025 @default.
- W2187736685 cites W2045866553 @default.
- W2187736685 cites W2048808743 @default.
- W2187736685 cites W2049490335 @default.
- W2187736685 cites W2049769212 @default.
- W2187736685 cites W2053270784 @default.
- W2187736685 cites W2053860396 @default.
- W2187736685 cites W2055002273 @default.
- W2187736685 cites W2055589857 @default.
- W2187736685 cites W2057896213 @default.
- W2187736685 cites W2059273534 @default.
- W2187736685 cites W2059308008 @default.
- W2187736685 cites W2061180610 @default.
- W2187736685 cites W206629481 @default.
- W2187736685 cites W2068819405 @default.
- W2187736685 cites W2069176919 @default.
- W2187736685 cites W2073432906 @default.
- W2187736685 cites W2082024168 @default.
- W2187736685 cites W2086026094 @default.
- W2187736685 cites W2088390218 @default.
- W2187736685 cites W2088671515 @default.
- W2187736685 cites W2089920144 @default.
- W2187736685 cites W2091364723 @default.
- W2187736685 cites W2091995773 @default.
- W2187736685 cites W2093921289 @default.
- W2187736685 cites W2094121810 @default.
- W2187736685 cites W2098301459 @default.
- W2187736685 cites W2100648267 @default.
- W2187736685 cites W2103240277 @default.
- W2187736685 cites W2105315411 @default.
- W2187736685 cites W2107007398 @default.
- W2187736685 cites W2108860858 @default.
- W2187736685 cites W2112229259 @default.
- W2187736685 cites W2117116688 @default.
- W2187736685 cites W2117223239 @default.
- W2187736685 cites W2122608403 @default.
- W2187736685 cites W2122782850 @default.
- W2187736685 cites W2123836140 @default.
- W2187736685 cites W2125743967 @default.
- W2187736685 cites W2126546276 @default.