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- W2187737278 abstract "2 Abstract: In the present study we have synthesized a series of 2-substituted-9-chloro-8-fluoropyrimido (2,1-b)benzothiazole-3-cyano-4(H)-ones. These series was synthesized by the reaction of 9-chloro-8- fluoropyrimido(2,1-b)benzothiazole-2-thiomethyl-3-cyano-4(H)-one with various arylamino in the presence of dimethyl formamide and anhydrous potassium carbonate. 9-chloro-8-fluoropyrimido (2,1-b)benzothiazole-2- thiomethyl-3-cyano-4(H)-ones were prepared by condensation of 2-amino-7-chloro-6-fluorobenzothiazole with ethyl-2-cyano-3,3-bismethylthio acrylate in the presence of dimethyl formamide and anhydrous potassium carbonate. All the synthesized compounds were screened for their anti-inflammatory activity in-vitro and in-vivo, antibacterial and antifungal activity. Selected compounds were also subjected for analgesic activity by acetic acid induced writhing method in albino mice." @default.
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- W2187737278 date "2009-01-01" @default.
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- W2187737278 title "Synthesis and pharmacological screening of some novel 2-arylhydrazino and 2-aryloxy-pyrimido [2,1-b] benzothiazole derivatives." @default.
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