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- W2187766998 abstract "Inthefission yeast, Schizosaccharomyces pombe, tolerance tohighsodiumandlithium concentrations requires thefunctioning ofthesod2, Na+/H+antiporter. We havedirectly measured theactivity ofthisantiporter and demonstrated reconstitution oftheactivity ingenedeletion strains. Inaddition, wehaveshownthat itcanbetransferred to,anditsantiporter activity detected in,thebudding yeast, Saccharomyces cerevisiae, whereitalsoconfers sodiumand lithium tolerance. Proton fluxthrough theS.pombeNa+/H+ antiporter wasdirectly measured usingmicrophysiometry. Thedirection oftransmembrane proton flux mediated bythis antiporter wasreversible, withprotons beingimported or exported inresponse totheexternal concentration ofsodium. Thisbidirectional activity wasalsodetected inS.cerevisiae strains expressing sod2andexpression ofthis genecomple- mentedthesodiumandlithium sensitivity resulting from inactivation oftheENAI/PMR2encoded Na+-exporting AT- Pases. Thissuggests that antiporters orsodium pumpscanbe utilized interchangeably byS.cerevisiae toregulate internal sodium concentration. Potent inhibitors ofmammalian Na+/ H+exchangers werefoundtohavenoeffect onsod2activity. Theproton fluxmediated bysod2wasalsofoundtobe unaffected byperturbation ofmembranepotential orthe plasma membraneproton gradient." @default.
- W2187766998 created "2016-06-24" @default.
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- W2187766998 date "1996-01-01" @default.
- W2187766998 modified "2023-09-27" @default.
- W2187766998 title "Functional expression oftheSchizosaccharomyces" @default.
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- W2187766998 hasPublicationYear "1996" @default.
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