Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187773005> ?p ?o ?g. }
- W2187773005 endingPage "1793" @default.
- W2187773005 startingPage "1780" @default.
- W2187773005 abstract "To elucidate the cellular role of the heterotrimeric G protein G(o), we have taken a molecular genetic approach in Caenorhabditis elegans. We screened for suppressors of activated GOA-1 (G(o)alpha) that do not simply decrease its expression and found mutations in only two genes, sag-1 and eat-16. Animals defective in either gene display a hyperactive phenotype similar to that of goa-1 loss-of-function mutants. Double-mutant analysis indicates that both sag-1 and eat-16 act downstream of, or parallel to, G(o)alpha and negatively regulate EGL-30 (G(q)alpha) signaling. eat-16 encodes a regulator of G protein signaling (RGS) most similar to the mammalian RGS7 and RGS9 proteins and can inhibit endogenous mammalian G(q)/G(11) in COS-7 cells. Animals defective in both sag-1 and eat-16 are inviable, but reducing function in egl-30 restores viability, indicating that the lethality of the eat-16; sag-1 double mutant is due to excessive G(q)alpha activity. Analysis of these mutations indicates that the G(o) and G(q) pathways function antagonistically in C. elegans, and that G(o)alpha negatively regulates the G(q) pathway, possibly via EAT-16 or SAG-1. We propose that a major cellular role of G(o) is to antagonize signaling by G(q)." @default.
- W2187773005 created "2016-06-24" @default.
- W2187773005 creator A5023992014 @default.
- W2187773005 creator A5028178456 @default.
- W2187773005 creator A5033624132 @default.
- W2187773005 creator A5034690690 @default.
- W2187773005 creator A5067974917 @default.
- W2187773005 date "1999-07-15" @default.
- W2187773005 modified "2023-10-16" @default.
- W2187773005 title "Antagonism between Goalpha and Gqalpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Goalpha signaling and regulates Gqalpha activity" @default.
- W2187773005 cites W1489654012 @default.
- W2187773005 cites W1525329782 @default.
- W2187773005 cites W1570939625 @default.
- W2187773005 cites W1582485749 @default.
- W2187773005 cites W1844425425 @default.
- W2187773005 cites W1847602617 @default.
- W2187773005 cites W1870738472 @default.
- W2187773005 cites W1903146305 @default.
- W2187773005 cites W1944127002 @default.
- W2187773005 cites W1948927501 @default.
- W2187773005 cites W1967293169 @default.
- W2187773005 cites W1968565058 @default.
- W2187773005 cites W1972760976 @default.
- W2187773005 cites W1973613428 @default.
- W2187773005 cites W1977493444 @default.
- W2187773005 cites W1977598234 @default.
- W2187773005 cites W1980166477 @default.
- W2187773005 cites W1982997682 @default.
- W2187773005 cites W1983278156 @default.
- W2187773005 cites W1992194142 @default.
- W2187773005 cites W1993466966 @default.
- W2187773005 cites W1993485378 @default.
- W2187773005 cites W1993678582 @default.
- W2187773005 cites W2003078610 @default.
- W2187773005 cites W2004020532 @default.
- W2187773005 cites W2005189737 @default.
- W2187773005 cites W2006547317 @default.
- W2187773005 cites W2006640982 @default.
- W2187773005 cites W2009821005 @default.
- W2187773005 cites W2016923687 @default.
- W2187773005 cites W2017663972 @default.
- W2187773005 cites W2026068903 @default.
- W2187773005 cites W2029445497 @default.
- W2187773005 cites W2035633569 @default.
- W2187773005 cites W2038366562 @default.
- W2187773005 cites W2045291272 @default.
- W2187773005 cites W2050307742 @default.
- W2187773005 cites W2056328047 @default.
- W2187773005 cites W2059946923 @default.
- W2187773005 cites W2060584742 @default.
- W2187773005 cites W2064183491 @default.
- W2187773005 cites W2071242185 @default.
- W2187773005 cites W2073223681 @default.
- W2187773005 cites W2077094786 @default.
- W2187773005 cites W2090091413 @default.
- W2187773005 cites W2090636422 @default.
- W2187773005 cites W2091240754 @default.
- W2187773005 cites W2095013577 @default.
- W2187773005 cites W2097422684 @default.
- W2187773005 cites W2108080306 @default.
- W2187773005 cites W2108280966 @default.
- W2187773005 cites W2108471057 @default.
- W2187773005 cites W2110458673 @default.
- W2187773005 cites W2118731910 @default.
- W2187773005 cites W2122163057 @default.
- W2187773005 cites W2122470243 @default.
- W2187773005 cites W2140909611 @default.
- W2187773005 cites W2146386420 @default.
- W2187773005 cites W2151360724 @default.
- W2187773005 cites W2158016476 @default.
- W2187773005 cites W2407549567 @default.
- W2187773005 cites W4230501579 @default.
- W2187773005 cites W4248350370 @default.
- W2187773005 doi "https://doi.org/10.1101/gad.13.14.1780" @default.
- W2187773005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316886" @default.
- W2187773005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10421631" @default.
- W2187773005 hasPublicationYear "1999" @default.
- W2187773005 type Work @default.
- W2187773005 sameAs 2187773005 @default.
- W2187773005 citedByCount "174" @default.
- W2187773005 countsByYear W21877730052012 @default.
- W2187773005 countsByYear W21877730052013 @default.
- W2187773005 countsByYear W21877730052014 @default.
- W2187773005 countsByYear W21877730052015 @default.
- W2187773005 countsByYear W21877730052016 @default.
- W2187773005 countsByYear W21877730052017 @default.
- W2187773005 countsByYear W21877730052018 @default.
- W2187773005 countsByYear W21877730052020 @default.
- W2187773005 countsByYear W21877730052021 @default.
- W2187773005 countsByYear W21877730052022 @default.
- W2187773005 countsByYear W21877730052023 @default.
- W2187773005 crossrefType "journal-article" @default.
- W2187773005 hasAuthorship W2187773005A5023992014 @default.
- W2187773005 hasAuthorship W2187773005A5028178456 @default.
- W2187773005 hasAuthorship W2187773005A5033624132 @default.
- W2187773005 hasAuthorship W2187773005A5034690690 @default.
- W2187773005 hasAuthorship W2187773005A5067974917 @default.
- W2187773005 hasBestOaLocation W21877730051 @default.