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• W2187777340 abstract "RESUMEN Introduccion: El acido folico se considera una molecula fundamental durante el desarrollo cerebral fetal. No hay claridad sobre el beneficio de esta intervencion durante el embarazo para la reduccion del riesgo de trastornos del espectro autista. Objetivo: Analizar la evidencia disponible entre el consumo de acido folico en el periodo periconcepcional y la presencia de los trastornos del espectro autista a traves de una revision bibliografica. Materiales y metodos: Busqueda en base de datos Pubmed y Clinical Trials utilizando los terminos MeSH: “folic acid”, “autism”y “pregnancy”. Se incluyeron articulos de revision y originales, en ingles y espanol, sin importar fecha de publicacion. Resultados y discusion: Con la estrategia de busqueda se encontraron inicialmente 90 estudios potenciales pero despues de aplicar los criterios de inclusion culmina en cuatro estudios observacionales, dos de casos y controles, uno de cohorte y un estudio ecologico donde se evalua la asociacion en cuestion en dicho periodo critico. Defectos en la metilacion corregidos con la administracion de suplementos de acido folico podrian explicar el potencial benefico en la prevencion de trastornos del espectro autista. Conclusiones: La evidencia es escasa y poco consistente en evaluar si la ingesta de acido folico durante el periodo periconcepcional se constituye en un factor protector para el desarrollo de los trastornos del espectro autista. MED UIS. 2015;28(3):327-36. Palabras clave: Acido folico. Trastornos del espectro autista. Embarazo. Prevencion primaria. ABSTRACT Introduction: Folic acid is considered an key molecule during fetal brain development. There have been potential benefits of this intervention during pregnancy such as reducing the risk of autism spectrum disorders. Objective: To analyze the evidence of folic acid in the periconceptional period for the prevention of autism spectrum disorders through a literature review. Materials and methods: A search of scientific articles was conducted in PubMed data base and Clinical Trials during the months of August 2014 to March 2015. The MeSH terms used were “folic acid”, “autism” and “pregnancy”. Review and original articles in English and Spanish are included, regardless of date of publication. Results: Four observational studies were found where the association is evaluated: two case-control, one cohort and one ecological study. Contradictory results are described, associated with the methodology of the studies. Methylation defects corrected with supplementation of folic acid could explain the potential benefit in preventing autism spectrum disorders. Conclusions: The evidence limited and inconsistent establishing that the intake of folic acid during the periconceptional period constitutes a protective factor for the development of autism spectrum disorders. MED UIS. 2015;28(3):327-36. Keywords: Folic acid. Autistic Disorder. Pregnancy. Primary Prevention." @default.
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• W2187777340 title "Consumo de ácido fólico en el embarazo y reducción del riesgo de trastornos del espectro autista" @default.
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