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- W2187781353 abstract "Orally fast dissolving films became a novel approach to oral drug delivery system as they provide convenience and ease of use over other dosage forms. The aim of this study was to formulate fast dissolving films of zaleplon (ZAL), a drug indicated for short term management of insomnia. Zaleplon solubility was increased by complexation with β-cyclodextrin. The inclusion complex was proven by differential scanning calorimetry (DSC) and fourier transformation-infrared spectroscopy (FTIR). Different film forming polymers used were instant pure-cote, HPMC E15, lycoat NG73 and kollicoate IR with propylene glycol as a plasticizer. The prepared films were evaluated for film thickness, folding endurance, drug content, disintegration time and in vitro dissolution. The In vitro drug dissolution studies were carried out in distilled water and formulation containing kollicoate IR showed a complete drug release in the first 10 minutes and an In vitro disintegration time of 32.9 seconds. Zaleplon, has been reported to increase melatonin secretion in healthy human beings suggesting an influence of zaleplon on chronobiology. Zaleplon fast dissolving films were found to increase the melatonin level in human serum when compared with market tablets. The Area Under the Curve for mean melatonin concentration in both zaleplon films and market tablets during the first eight hours was found to be 410.93 and 217.32 respectively." @default.
- W2187781353 created "2016-06-24" @default.
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- W2187781353 date "2014-01-01" @default.
- W2187781353 modified "2023-09-27" @default.
- W2187781353 title "PREPARATION AND EVALUATION OF ZALEPLON FAST DISSOLVING FILMS USING DIFFERENT FILM FORMING POLYMERS" @default.
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