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• W2187789716 abstract "The effects of indomethacin on refractoriness following exercise both with and without a bronchoconstrictor response. B.A. Wilson, O. Bar-Or, P.M. O'Byrne. ERS Journals Ltd 1994. ABSTRACT: Repeated exercise tests demonstrate refractoriness to the develop- ment of exercise-induced asthma (EIA). It is unclear whether it is the initial exer- cise per se or the resulting bronchoconstriction that causes the attenuated response to the second exercise challenge. This study was designed to determine whether the reported blocking of the refractory period by indomethacin requires a significant bronchoconstriction following the primary exercise challenge. Thirteen asthmatic teenagers (aged 12-16 yrs) were tested on four visits. Each visit included two 7 min treadmill exercise challenges at 80% maximum heart rate, separated by a 30 min rest. Conditions for the second exercise challenge (Ch2) were always thermoneutral (20-22°C and 25-35% relative humidity (RH); whilst chal- lenge one (Ch1) was completed twice in thermoneutral and twice in warm-humid breathing conditions (33-35°C and 90-95% RH). A pretreatment for 3 days in a double-blind design with either placebo or indomethacin was completed. Forced expiratory volume in one second (FEV 1 ) was measured before and repeatedly fol- lowing each challenge. The % fall in FEV 1 following Ch1 of the placebo ther- moneutral trial was taken as reference. Percent at each visit was expressed as the decrease in EIA following Ch2, compared to reference. Warm-humid breathing reduced the EIA post Ch1 by 75%, whilst providing sim- ilar protection to thermoneutral conditions. Indomethacin had no significant effect on EIA after Ch1, but reduced percent for both warm-humid (from 67 to 16%) and thermoneutral (from 70 to 26%) conditions. The data indicate that inhibitory prostaglandins play a major role in EIA refrac- toriness and suggest that the release of these prostaglandins is initiated by some exercise factor, independent of the development of bronchoconstriction." @default.
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• W2187789716 date "1994-01-01" @default.
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• W2187789716 title "The e effects o of iindomethacin o on rrefractoriness ffollowing exercise b both w with a and w without a a b bronchoconstrictor rresponse" @default.
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