Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187854548> ?p ?o ?g. }
- W2187854548 endingPage "17" @default.
- W2187854548 startingPage "11" @default.
- W2187854548 abstract "It has been postulated that the in vivo toxicity of asbestos results from its catalysis of free radical generation. We examined in vivo radical production using electron spin resonance (ESR) coupled with the spin trap α-(4-pyridyl-1-oxide)-N-t-butylnitrone (4-POBN); 180 day-old rats were intratracheally instilled with either 500 μg crocidolite or saline. Twenty-four hours later, histologic examination revealed a neutrophilic inflammatory response. ESR spectroscopy of the chloroform extract from lungs exposed to asbestos gave a spectrum consistent with a carbon-centered radical adduct, while those spectra from lungs instilled with saline revealed a much weaker signal. This same radical formation persisted and, even one month after instillation, could be detected in the lungs of rats exposed to asbestos. The 4-POBN adducts detected by ESR are very similar to, if not identical with, ethyl and pentyl radical adducts, providing evidence of in vivo lipid peroxidation resulting from asbestos exposure. We conclude that, after instillation of crocidolite in the rat, ESR analysis of lung tissue demonstrates in vivo free radical production." @default.
- W2187854548 created "2016-06-24" @default.
- W2187854548 creator A5010535636 @default.
- W2187854548 creator A5015414029 @default.
- W2187854548 creator A5017261720 @default.
- W2187854548 creator A5018151824 @default.
- W2187854548 date "1998-01-01" @default.
- W2187854548 modified "2023-10-16" @default.
- W2187854548 title "In Vivo Evidence of Free Radical Formation After Asbestos Instillation" @default.
- W2187854548 cites W1539048811 @default.
- W2187854548 cites W1963578253 @default.
- W2187854548 cites W1964218617 @default.
- W2187854548 cites W1970653700 @default.
- W2187854548 cites W1977109446 @default.
- W2187854548 cites W1981583867 @default.
- W2187854548 cites W1994635899 @default.
- W2187854548 cites W2007932404 @default.
- W2187854548 cites W2017408327 @default.
- W2187854548 cites W2017527366 @default.
- W2187854548 cites W2033918425 @default.
- W2187854548 cites W2034933587 @default.
- W2187854548 cites W2036417748 @default.
- W2187854548 cites W2036838168 @default.
- W2187854548 cites W2044167464 @default.
- W2187854548 cites W2046998600 @default.
- W2187854548 cites W2056201873 @default.
- W2187854548 cites W2059565496 @default.
- W2187854548 cites W2060026323 @default.
- W2187854548 cites W2063342387 @default.
- W2187854548 cites W2069849915 @default.
- W2187854548 cites W2084045246 @default.
- W2187854548 cites W2100319265 @default.
- W2187854548 cites W2119221986 @default.
- W2187854548 cites W2129758233 @default.
- W2187854548 cites W2135953209 @default.
- W2187854548 cites W2153578179 @default.
- W2187854548 cites W2154478515 @default.
- W2187854548 cites W2155328369 @default.
- W2187854548 cites W2249286470 @default.
- W2187854548 cites W2345715920 @default.
- W2187854548 cites W2405910659 @default.
- W2187854548 doi "https://doi.org/10.1016/s0891-5849(97)00063-4" @default.
- W2187854548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9436609" @default.
- W2187854548 hasPublicationYear "1998" @default.
- W2187854548 type Work @default.
- W2187854548 sameAs 2187854548 @default.
- W2187854548 citedByCount "39" @default.
- W2187854548 countsByYear W21878545482012 @default.
- W2187854548 countsByYear W21878545482013 @default.
- W2187854548 countsByYear W21878545482014 @default.
- W2187854548 countsByYear W21878545482016 @default.
- W2187854548 countsByYear W21878545482017 @default.
- W2187854548 crossrefType "journal-article" @default.
- W2187854548 hasAuthorship W2187854548A5010535636 @default.
- W2187854548 hasAuthorship W2187854548A5015414029 @default.
- W2187854548 hasAuthorship W2187854548A5017261720 @default.
- W2187854548 hasAuthorship W2187854548A5018151824 @default.
- W2187854548 hasConcept C108204754 @default.
- W2187854548 hasConcept C139066938 @default.
- W2187854548 hasConcept C150903083 @default.
- W2187854548 hasConcept C178790620 @default.
- W2187854548 hasConcept C185592680 @default.
- W2187854548 hasConcept C191897082 @default.
- W2187854548 hasConcept C192562407 @default.
- W2187854548 hasConcept C207001950 @default.
- W2187854548 hasConcept C2778004101 @default.
- W2187854548 hasConcept C2778815226 @default.
- W2187854548 hasConcept C2780829032 @default.
- W2187854548 hasConcept C510490043 @default.
- W2187854548 hasConcept C55493867 @default.
- W2187854548 hasConcept C86803240 @default.
- W2187854548 hasConceptScore W2187854548C108204754 @default.
- W2187854548 hasConceptScore W2187854548C139066938 @default.
- W2187854548 hasConceptScore W2187854548C150903083 @default.
- W2187854548 hasConceptScore W2187854548C178790620 @default.
- W2187854548 hasConceptScore W2187854548C185592680 @default.
- W2187854548 hasConceptScore W2187854548C191897082 @default.
- W2187854548 hasConceptScore W2187854548C192562407 @default.
- W2187854548 hasConceptScore W2187854548C207001950 @default.
- W2187854548 hasConceptScore W2187854548C2778004101 @default.
- W2187854548 hasConceptScore W2187854548C2778815226 @default.
- W2187854548 hasConceptScore W2187854548C2780829032 @default.
- W2187854548 hasConceptScore W2187854548C510490043 @default.
- W2187854548 hasConceptScore W2187854548C55493867 @default.
- W2187854548 hasConceptScore W2187854548C86803240 @default.
- W2187854548 hasIssue "1" @default.
- W2187854548 hasLocation W21878545481 @default.
- W2187854548 hasLocation W21878545482 @default.
- W2187854548 hasOpenAccess W2187854548 @default.
- W2187854548 hasPrimaryLocation W21878545481 @default.
- W2187854548 hasRelatedWork W2009832011 @default.
- W2187854548 hasRelatedWork W2031997549 @default.
- W2187854548 hasRelatedWork W2061880770 @default.
- W2187854548 hasRelatedWork W2085781744 @default.
- W2187854548 hasRelatedWork W2098407326 @default.
- W2187854548 hasRelatedWork W2276209953 @default.
- W2187854548 hasRelatedWork W2332295699 @default.
- W2187854548 hasRelatedWork W2384752203 @default.