FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187865612> ?p ?o ?g. }

• W2187865612 endingPage "136" @default.
• W2187865612 startingPage "129" @default.
• W2187865612 abstract "It was the aim of this study to develop an oral self-emulsifying drug delivery system (SEDDS) for the peptide drug daptomycin exhibiting an anionic net charge. Drug lipophilicity was increased by hydrophobic ion pairing with cationic surfactant dodecylamine hydrochloride in molar ratio of surfactant to peptide 5:1. Log P (octanol/water) of -5.0 was even raised to +4.8 due to complexation with dodecylamine hydrochloride. Various SEDDS formulations were developed and characterised regarding emulsification properties, droplet size, polydispersity index and zeta potential. When the daptomycin dodecylamine complex (DAP/DOA) was dissolved in a formulation containing 35% Dermofeel MCT, 30% Capmul MCM and 35% Cremophor RH40, a maximum payload of even 8.0% (w/w) corresponding to 5.5% pure daptomycin was achieved. The formulation was degraded by lipase within 90min. Release studies of daptomycin from this formulation emulsified in 50mM phosphate buffer pH6.8 demonstrated a sustained drug release for at least six hours. Moreover, SEDDS exhibited also mucus permeating properties as well as a protective effect towards drug degradation by α-chymotrypsin. According to these results, SEDDS containing 8% DAP/DOA complex may be considered as a new potential oral delivery system for daptomycin." @default.
• W2187865612 created "2016-06-24" @default.
• W2187865612 creator A5035632031 @default.
• W2187865612 creator A5038161927 @default.
• W2187865612 creator A5083682436 @default.
• W2187865612 creator A5087932810 @default.
• W2187865612 creator A5091156898 @default.
• W2187865612 date "2016-01-01" @default.
• W2187865612 modified "2023-10-12" @default.
• W2187865612 title "Development and in vitro characterisation of an oral self-emulsifying delivery system for daptomycin" @default.
• W2187865612 cites W1546501979 @default.
• W2187865612 cites W1774514443 @default.
• W2187865612 cites W1930151427 @default.
• W2187865612 cites W1964172500 @default.
• W2187865612 cites W1973886808 @default.
• W2187865612 cites W1980445682 @default.
• W2187865612 cites W1986477299 @default.
• W2187865612 cites W1988228524 @default.
• W2187865612 cites W1988895992 @default.
• W2187865612 cites W1991431841 @default.
• W2187865612 cites W1999942286 @default.
• W2187865612 cites W2004195339 @default.
• W2187865612 cites W2011068615 @default.
• W2187865612 cites W2022905205 @default.
• W2187865612 cites W2035990801 @default.
• W2187865612 cites W2043037492 @default.
• W2187865612 cites W2049764487 @default.
• W2187865612 cites W2055249600 @default.
• W2187865612 cites W2058840084 @default.
• W2187865612 cites W2075379117 @default.
• W2187865612 cites W2076609240 @default.
• W2187865612 cites W2080540805 @default.
• W2187865612 cites W2082322552 @default.
• W2187865612 cites W2138742841 @default.
• W2187865612 cites W2139155301 @default.
• W2187865612 cites W2150855779 @default.
• W2187865612 cites W2154557683 @default.
• W2187865612 cites W2166547808 @default.
• W2187865612 doi "https://doi.org/10.1016/j.ejps.2015.10.005" @default.
• W2187865612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26485536" @default.
• W2187865612 hasPublicationYear "2016" @default.
• W2187865612 type Work @default.
• W2187865612 sameAs 2187865612 @default.
• W2187865612 citedByCount "58" @default.
• W2187865612 countsByYear W21878656122016 @default.
• W2187865612 countsByYear W21878656122017 @default.
• W2187865612 countsByYear W21878656122018 @default.
• W2187865612 countsByYear W21878656122019 @default.
• W2187865612 countsByYear W21878656122020 @default.
• W2187865612 countsByYear W21878656122021 @default.
• W2187865612 countsByYear W21878656122022 @default.
• W2187865612 countsByYear W21878656122023 @default.
• W2187865612 crossrefType "journal-article" @default.
• W2187865612 hasAuthorship W2187865612A5035632031 @default.
• W2187865612 hasAuthorship W2187865612A5038161927 @default.
• W2187865612 hasAuthorship W2187865612A5083682436 @default.
• W2187865612 hasAuthorship W2187865612A5087932810 @default.
• W2187865612 hasAuthorship W2187865612A5091156898 @default.
• W2187865612 hasConcept C11432220 @default.
• W2187865612 hasConcept C155672457 @default.
• W2187865612 hasConcept C171250308 @default.
• W2187865612 hasConcept C178790620 @default.
• W2187865612 hasConcept C185592680 @default.
• W2187865612 hasConcept C192552737 @default.
• W2187865612 hasConcept C192562407 @default.
• W2187865612 hasConcept C201399114 @default.
• W2187865612 hasConcept C2777239854 @default.
• W2187865612 hasConcept C2778651397 @default.
• W2187865612 hasConcept C2778980435 @default.
• W2187865612 hasConcept C2779489039 @default.
• W2187865612 hasConcept C2779820397 @default.
• W2187865612 hasConcept C43617362 @default.
• W2187865612 hasConcept C523546767 @default.
• W2187865612 hasConcept C54355233 @default.
• W2187865612 hasConcept C55493867 @default.
• W2187865612 hasConcept C58226133 @default.
• W2187865612 hasConcept C86181022 @default.
• W2187865612 hasConcept C86803240 @default.
• W2187865612 hasConceptScore W2187865612C11432220 @default.
• W2187865612 hasConceptScore W2187865612C155672457 @default.
• W2187865612 hasConceptScore W2187865612C171250308 @default.
• W2187865612 hasConceptScore W2187865612C178790620 @default.
• W2187865612 hasConceptScore W2187865612C185592680 @default.
• W2187865612 hasConceptScore W2187865612C192552737 @default.
• W2187865612 hasConceptScore W2187865612C192562407 @default.
• W2187865612 hasConceptScore W2187865612C201399114 @default.
• W2187865612 hasConceptScore W2187865612C2777239854 @default.
• W2187865612 hasConceptScore W2187865612C2778651397 @default.
• W2187865612 hasConceptScore W2187865612C2778980435 @default.
• W2187865612 hasConceptScore W2187865612C2779489039 @default.
• W2187865612 hasConceptScore W2187865612C2779820397 @default.
• W2187865612 hasConceptScore W2187865612C43617362 @default.
• W2187865612 hasConceptScore W2187865612C523546767 @default.
• W2187865612 hasConceptScore W2187865612C54355233 @default.
• W2187865612 hasConceptScore W2187865612C55493867 @default.
• W2187865612 hasConceptScore W2187865612C58226133 @default.
• W2187865612 hasConceptScore W2187865612C86181022 @default.
• W2187865612 hasConceptScore W2187865612C86803240 @default.

• next