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- W2187890775 abstract "Summary Objective: To ascertain the diuretic potential of the leaves and stem bark of Michelia champaca L. an Indian medicinal plant widely used for the purpose in traditional systems of medicine. Methods: Aqueous extracts of Michelia champaca leaves and stem bark dosed at 250 and 500 mg/kg each were administered to adult Swiss albino Wistar rats previously maintained at a uniform water and salt load, and the effect on urinary electrolyte concentrations was determined. The urine output was quantitated at several intervals during the 24 hour collection. Results: The higher doses of both the leaves and stem bark aqueous extracts exhibited a more promising diuretic potential. Maximal diuretic response was observed in the 500 mg/kg dose of Michelia champaca stem bark aqueous extract, which closely approximated the results for the standard drug Furosemide. Both the doses of stem bark extracts elicited greater volumes of urine and were comparable to that achieved with the standard drug. Conclusion : The aqueous extracts of stem bark afforded a better diuretic potential in comparison to the leaves extract, the higher dose evoking pronounced diuresis even greater than the standard Furosemide in terms of Na + and K + concentrations and closely approximating Furosemide values in terms of urine volume." @default.
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- W2187890775 date "2011-01-01" @default.
- W2187890775 modified "2023-09-26" @default.
- W2187890775 title "DIURETIC ACTIVITY OF AQUEOUS EXTRACTS OF MICHELIA CHAMPACA L. LEAVES AD STEM BARK IRATS" @default.
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