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- W2187908233 abstract "Animalstudiessuggesttheneurotransmitterdopamine(DA)playsanimportantroleindecision-making.Inrats,DAdepletiondecreases toleranceforeffortandprobabilitycosts,whiledrugsenhancingDAincreasetoleranceforthesecosts.However,dataregardingtheeffect of DA manipulations on effort and probability costs in humans remain scarce. The current study examined acute effects of d-amphetamine,anindirectDAagonist,onwillingnessofhealthyhumanvolunteerstoexerteffortformonetaryrewardsatvaryinglevels of reward value and reward probability. Based on preclinical research, we predicted amphetamine would increase exertion of effort, particularlywhenrewardprobabilitywaslow.Overthreesessions,17healthynormaladultsreceivedplacebo,d-amphetamine10mg,and 20mgundercounterbalanceddouble-blindconditionsandcompletedtheEffortExpenditureforRewardsTask.Consistentwithpredictions, amphetamine enhanced willingness to exert effort, particularly when reward probability was lower. Amphetamine did not alter effects of reward magnitude on willingness to exert effort. Amphetamine sped task performance, but its psychomotor effects were not strongly related to its effects on decision-making. This is the first demonstration in humans that dopaminergic manipulations alter willingnesstoexerteffortforrewards.Thesefindingshelpelucidateneurochemicalsubstratesofchoice,withimplicationsforneuropsychiatricdiseasescharacterizedbydopaminergicdysfunctionandmotivationaldeficits." @default.
- W2187908233 created "2016-06-24" @default.
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- W2187908233 date "2011-01-01" @default.
- W2187908233 modified "2023-09-27" @default.
- W2187908233 title "AmpingUpEffort:Effectsofd-AmphetamineonHuman Effort-BasedDecision-Making" @default.
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