FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187910001> ?p ?o ?g. }

• W2187910001 endingPage "176" @default.
• W2187910001 startingPage "167" @default.
• W2187910001 abstract "Tumor cells have developed several strategies to escape the immune system. One of these strategies consists of the secretion of immunosuppressive factors like interleukin-10 or prostaglandin E2 (PGE2), which impair the immune system. We have demonstrated recently that tumor-derived PGE2 down-regulates the expression of the integrin Mac-1 and the chemokine receptor CCR5 on primary monocytes, resulting in reduced adhesion and migration.In order to identify new target genes for tumor-derived factors in monocytes, we set up an in vitro system consisting of cDNA micro arrays and 2D gel electrophoresis.We identified 25 genes that were differentially expressed upon incubation of cells in conditioned tumor cell supernatants as compared to cells incubated in cell culture medium. We describe in more detail that IL-1β secretion is induced by tumor supernatants and that IL-1β overexpression is also evident in monocytes from tumor patients in vivo, where expression correlates with the tumor stage. In addition, up-regulation of the plasminogen activator inhibitor-2, PAI-2, and down-regulation of the urokinase-type plasminogen activator receptor, uPAR, resulted in a reduced capability of monocytes to degrade and invade extracellular matrices.In summary, we describe interesting novel targets of soluble tumor-derived factors that are probably involved in the tumor-mediated immunosuppression commonly found in cancer patients." @default.
• W2187910001 created "2016-06-24" @default.
• W2187910001 creator A5030649192 @default.
• W2187910001 creator A5035674091 @default.
• W2187910001 creator A5051943847 @default.
• W2187910001 creator A5058391960 @default.
• W2187910001 creator A5067582099 @default.
• W2187910001 creator A5084998138 @default.
• W2187910001 date "2004-03-01" @default.
• W2187910001 modified "2023-09-26" @default.
• W2187910001 title "New Target Genes for Tumor-derived Soluble Factors in Primary Monocytes." @default.
• W2187910001 cites W1506033553 @default.
• W2187910001 cites W1657916616 @default.
• W2187910001 cites W1673084462 @default.
• W2187910001 cites W1943059672 @default.
• W2187910001 cites W1947079675 @default.
• W2187910001 cites W1967478221 @default.
• W2187910001 cites W1992637561 @default.
• W2187910001 cites W2013994536 @default.
• W2187910001 cites W2023437882 @default.
• W2187910001 cites W2024039001 @default.
• W2187910001 cites W2036112796 @default.
• W2187910001 cites W2048657818 @default.
• W2187910001 cites W2057801614 @default.
• W2187910001 cites W2078594804 @default.
• W2187910001 cites W2087459726 @default.
• W2187910001 cites W2095864883 @default.
• W2187910001 cites W2124314287 @default.
• W2187910001 cites W2126924926 @default.
• W2187910001 cites W2137375900 @default.
• W2187910001 cites W2144634347 @default.
• W2187910001 cites W2167777549 @default.
• W2187910001 cites W2204281226 @default.
• W2187910001 cites W2278969192 @default.
• W2187910001 cites W2281508338 @default.
• W2187910001 cites W2411839043 @default.
• W2187910001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31394681" @default.
• W2187910001 hasPublicationYear "2004" @default.
• W2187910001 type Work @default.
• W2187910001 sameAs 2187910001 @default.
• W2187910001 citedByCount "0" @default.
• W2187910001 crossrefType "journal-article" @default.
• W2187910001 hasAuthorship W2187910001A5030649192 @default.
• W2187910001 hasAuthorship W2187910001A5035674091 @default.
• W2187910001 hasAuthorship W2187910001A5051943847 @default.
• W2187910001 hasAuthorship W2187910001A5058391960 @default.
• W2187910001 hasAuthorship W2187910001A5067582099 @default.
• W2187910001 hasAuthorship W2187910001A5084998138 @default.
• W2187910001 hasConcept C13373296 @default.
• W2187910001 hasConcept C134018914 @default.
• W2187910001 hasConcept C153911025 @default.
• W2187910001 hasConcept C170493617 @default.
• W2187910001 hasConcept C203014093 @default.
• W2187910001 hasConcept C2776107976 @default.
• W2187910001 hasConcept C2779679481 @default.
• W2187910001 hasConcept C2781184567 @default.
• W2187910001 hasConcept C49039625 @default.
• W2187910001 hasConcept C502942594 @default.
• W2187910001 hasConcept C54355233 @default.
• W2187910001 hasConcept C55493867 @default.
• W2187910001 hasConcept C56219504 @default.
• W2187910001 hasConcept C81885089 @default.
• W2187910001 hasConcept C86803240 @default.
• W2187910001 hasConcept C8891405 @default.
• W2187910001 hasConcept C95444343 @default.
• W2187910001 hasConceptScore W2187910001C13373296 @default.
• W2187910001 hasConceptScore W2187910001C134018914 @default.
• W2187910001 hasConceptScore W2187910001C153911025 @default.
• W2187910001 hasConceptScore W2187910001C170493617 @default.
• W2187910001 hasConceptScore W2187910001C203014093 @default.
• W2187910001 hasConceptScore W2187910001C2776107976 @default.
• W2187910001 hasConceptScore W2187910001C2779679481 @default.
• W2187910001 hasConceptScore W2187910001C2781184567 @default.
• W2187910001 hasConceptScore W2187910001C49039625 @default.
• W2187910001 hasConceptScore W2187910001C502942594 @default.
• W2187910001 hasConceptScore W2187910001C54355233 @default.
• W2187910001 hasConceptScore W2187910001C55493867 @default.
• W2187910001 hasConceptScore W2187910001C56219504 @default.
• W2187910001 hasConceptScore W2187910001C81885089 @default.
• W2187910001 hasConceptScore W2187910001C86803240 @default.
• W2187910001 hasConceptScore W2187910001C8891405 @default.
• W2187910001 hasConceptScore W2187910001C95444343 @default.
• W2187910001 hasIssue "2" @default.
• W2187910001 hasLocation W21879100011 @default.
• W2187910001 hasOpenAccess W2187910001 @default.
• W2187910001 hasPrimaryLocation W21879100011 @default.
• W2187910001 hasRelatedWork W1514973779 @default.
• W2187910001 hasRelatedWork W2022489290 @default.
• W2187910001 hasRelatedWork W2050374169 @default.
• W2187910001 hasRelatedWork W2095532905 @default.
• W2187910001 hasRelatedWork W2317808311 @default.
• W2187910001 hasRelatedWork W2612699275 @default.
• W2187910001 hasRelatedWork W3156068899 @default.
• W2187910001 hasRelatedWork W3209395067 @default.
• W2187910001 hasRelatedWork W4280625423 @default.
• W2187910001 hasRelatedWork W4282542763 @default.
• W2187910001 hasVolume "1" @default.
• W2187910001 isParatext "false" @default.

• next