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• W2187913110 abstract "SUMMARY A technique in which the isolated spinal cord of South African frogs (Xenopus laevis) is prepared for neuro­ physiological studies is described. It was found that the isolated cord is suitable for testing synaptic efficiency and motoneurone excitability. A highly synchronized, high­ intensity monosynaptic spike potential was recorded from ventral root X after the application of a single stimulus to the ipsilateral dorsal root X. This response stayed fairly constant when stimulating at a frequency of 2/sec for a period of at least 5 minutes, Le. 700 consecutive responses. It is suggested that this isolated cord preparation can ~ be used to test the effect of pharmacological substances on synaptic efficiency and motoneurone excitability. To test its usefulness, the effect of Lucidril on these pheno­ mena was studied. It was found that Lucidril had a beneficial effect. It is concluded that the isolated spinal cord of the frog provides a satisfactory means of assessing the effect of pharmacological substances on motoneurone excitability and synaptic efficiency. S. Air. Med. J., 46, 203 (1972). Knowledge of the effect of pharmacological substances on the nervous system is still based mainly on biological tests and observations concerning its therapeutic value in cases of nervous disorders. The development of electrophysio­ logical techniques in neurophysiology during the last 2 decades also made it possible to observe the dir.x:t effect of such drugs on the reactivity of neurones, particularly spinal neurones, Le. spinal reflex activity. This concerns mainly the monosynaptic activation of spinal moto­ neurones. The monosynaptic response in such a reflex arc is dependent upon synaptic efficiency and motoneurone excitability. Intracellularly recorded excitatory postsynaptic potentials (EPSP) generated monosynaptically in moto­ neurones, provide a direct and quantitative measure~' Synaotic efficiency and motoneurone excitability can also satisfactorily be determined by recording the ventral nerve root responses after monosynaptic activation of the motoneurones.' The existence of a monosynaptic spinal reflex was first demonstrated by Renshaw' in the cat. It was also shown to exist in the spinal cord of the frog in situ.' Measurable, constant monosynaptic responses in the frog spinal cord were obtained mostly by means of a double-stimulus tech­ In the in situ preparation, substances are either administered intravenously or intrathecalIy. It is also aoplied dropwise directly onto the nervous tissue. In these circumstances it is impossible to have perfect control of the concentration of the substance that reaches the neurones under observation; it is also impossible to withdraw the substance at will. These problems can be solved by isolating the spinal cord and placing it in a special container through which different solutions can be run. Such a technique, in which the isolated spinal cords of South African frogs can be used to study the effect of different substances on synaptic efficiency and motoneurone excitability, as well as even­ tually on the activity of different types of spinal inter­ neurones, has been developed in this laboratory and is the subject of this article. It was found that with this technique a high-intensity, highly synchronized monosynaptic re­ sponse was obtained employing a single stimulus only, thus eliminating the complexity of the double-stimulus tech­ nique. To test the usefulness of the preparation the effect of Lucidril*, which is described as a neuroregulator, was investigated. It is claimed that this drug influences the metabolism of the nerve cell to promote the oxidation­ reduction processes and the metabolism of glucose, pro­ ducing a distinct and gradual psychological stimulation associated with a normalizing and regularizing effect on the nervous system. In this investigation the effect of Lucidril was studied on: (r) the intensity of the mono­ synaptic spike response which is a quantitative measure of the number of active motoneurones;' (ii) synchronization of the response, which indicates the number of neurones firing simultaneously (synchronization is assessed by the duration of the spike and smoothness of the spike); (iii) latency of the test response; and (iv) responsiveness and fatigue resistance when stimulating at a high frequency for prolonged periods." @default.
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• W2187913110 date "1972-02-26" @default.
• W2187913110 modified "2023-09-23" @default.
• W2187913110 title "Monosynaptic testing of synaptic efficiency and motoneurone excitability." @default.
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