FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187915989> ?p ?o ?g. }

• W2187915989 endingPage "10" @default.
• W2187915989 startingPage "2305" @default.
• W2187915989 abstract "We examined the effect of the combination of herpes simplex virus type1-thymidine kinase (HSV-TK)-suicide gene therapy and interleukin-21 (IL-21) immune gene therapy.To improve tumor specificity and the safety of gene therapy, we designed the suicide gene (HSV-TK) to be driven by midkine (MK) minimal promoter (MKp-TK). Plasmid DNA containing HSV-TK-suicide gene or IL-21 gene was injected into TE2 and Colon26 tumors developed in nude mice and electric pulses were then delivered.Tumors transduced with the MKp-TK gene demonstrated increased sensitivity to ganciclovir (GCV) in vitro and in vivo. MK minimal promoter conferred efficient transcriptional activity to the HSV-TK-suicide gene and in vivo electroporation was an effective method for transducing the MKp-TK gene. IL-21-transduced tumors disappeared completely in syngeneic BALB/c mice. However, the tumors were not suppressed completely in T-cell-depleted nude mice, and antitumor effects were absent in NK-cell-depleted mice. These data suggest that IL-21 induces T- and NK-cell-dependent antitumor effects. Furthermore, the growth of IL-21-producing tumors subsequently transduced with MKp-TK by electroporation was significantly retarded compared with control groups.Using the minimal promoter region of MK to drive the HSV-TK gene and in vivo electroporation to transduce IL-21 DNA into the tumors produced an efficient gene therapy with improved safety. To our knowledge, this is the first report of a combination gene therapy using HSV-TK/GCVand IL-21." @default.
• W2187915989 created "2016-06-24" @default.
• W2187915989 creator A5009925984 @default.
• W2187915989 creator A5026820167 @default.
• W2187915989 creator A5048881611 @default.
• W2187915989 creator A5057540866 @default.
• W2187915989 creator A5066055448 @default.
• W2187915989 creator A5067812959 @default.
• W2187915989 creator A5072883067 @default.
• W2187915989 creator A5073907487 @default.
• W2187915989 creator A5077175929 @default.
• W2187915989 date "2007-08-19" @default.
• W2187915989 modified "2023-09-26" @default.
• W2187915989 title "Combinatory gene therapy with electrotransfer of midkine promoter-HSV-TK and interleukin-21." @default.
• W2187915989 cites W1489777708 @default.
• W2187915989 cites W1513377274 @default.
• W2187915989 cites W1640053709 @default.
• W2187915989 cites W1989669523 @default.
• W2187915989 cites W1991271747 @default.
• W2187915989 cites W2007101178 @default.
• W2187915989 cites W2024018378 @default.
• W2187915989 cites W2032040395 @default.
• W2187915989 cites W2034510394 @default.
• W2187915989 cites W2035032239 @default.
• W2187915989 cites W2042487497 @default.
• W2187915989 cites W2043209647 @default.
• W2187915989 cites W2054131429 @default.
• W2187915989 cites W2067074969 @default.
• W2187915989 cites W2108371744 @default.
• W2187915989 cites W2120131414 @default.
• W2187915989 cites W2137693314 @default.
• W2187915989 cites W2144305464 @default.
• W2187915989 cites W2157154128 @default.
• W2187915989 cites W2163828646 @default.
• W2187915989 cites W2314632036 @default.
• W2187915989 cites W2317830877 @default.
• W2187915989 cites W2320304105 @default.
• W2187915989 cites W2399276654 @default.
• W2187915989 cites W2411714291 @default.
• W2187915989 cites W2413375710 @default.
• W2187915989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17695518" @default.
• W2187915989 hasPublicationYear "2007" @default.
• W2187915989 type Work @default.
• W2187915989 sameAs 2187915989 @default.
• W2187915989 citedByCount "7" @default.
• W2187915989 countsByYear W21879159892013 @default.
• W2187915989 countsByYear W21879159892015 @default.
• W2187915989 countsByYear W21879159892016 @default.
• W2187915989 crossrefType "journal-article" @default.
• W2187915989 hasAuthorship W2187915989A5009925984 @default.
• W2187915989 hasAuthorship W2187915989A5026820167 @default.
• W2187915989 hasAuthorship W2187915989A5048881611 @default.
• W2187915989 hasAuthorship W2187915989A5057540866 @default.
• W2187915989 hasAuthorship W2187915989A5066055448 @default.
• W2187915989 hasAuthorship W2187915989A5067812959 @default.
• W2187915989 hasAuthorship W2187915989A5072883067 @default.
• W2187915989 hasAuthorship W2187915989A5073907487 @default.
• W2187915989 hasAuthorship W2187915989A5077175929 @default.
• W2187915989 hasConcept C104317684 @default.
• W2187915989 hasConcept C111599444 @default.
• W2187915989 hasConcept C150903083 @default.
• W2187915989 hasConcept C153911025 @default.
• W2187915989 hasConcept C158074577 @default.
• W2187915989 hasConcept C159047783 @default.
• W2187915989 hasConcept C170493617 @default.
• W2187915989 hasConcept C186852380 @default.
• W2187915989 hasConcept C207001950 @default.
• W2187915989 hasConcept C2522874641 @default.
• W2187915989 hasConcept C2775960820 @default.
• W2187915989 hasConcept C2776147627 @default.
• W2187915989 hasConcept C2777965375 @default.
• W2187915989 hasConcept C2779820661 @default.
• W2187915989 hasConcept C2781196997 @default.
• W2187915989 hasConcept C34981463 @default.
• W2187915989 hasConcept C502942594 @default.
• W2187915989 hasConcept C54009773 @default.
• W2187915989 hasConcept C55493867 @default.
• W2187915989 hasConcept C86803240 @default.
• W2187915989 hasConceptScore W2187915989C104317684 @default.
• W2187915989 hasConceptScore W2187915989C111599444 @default.
• W2187915989 hasConceptScore W2187915989C150903083 @default.
• W2187915989 hasConceptScore W2187915989C153911025 @default.
• W2187915989 hasConceptScore W2187915989C158074577 @default.
• W2187915989 hasConceptScore W2187915989C159047783 @default.
• W2187915989 hasConceptScore W2187915989C170493617 @default.
• W2187915989 hasConceptScore W2187915989C186852380 @default.
• W2187915989 hasConceptScore W2187915989C207001950 @default.
• W2187915989 hasConceptScore W2187915989C2522874641 @default.
• W2187915989 hasConceptScore W2187915989C2775960820 @default.
• W2187915989 hasConceptScore W2187915989C2776147627 @default.
• W2187915989 hasConceptScore W2187915989C2777965375 @default.
• W2187915989 hasConceptScore W2187915989C2779820661 @default.
• W2187915989 hasConceptScore W2187915989C2781196997 @default.
• W2187915989 hasConceptScore W2187915989C34981463 @default.
• W2187915989 hasConceptScore W2187915989C502942594 @default.
• W2187915989 hasConceptScore W2187915989C54009773 @default.
• W2187915989 hasConceptScore W2187915989C55493867 @default.
• W2187915989 hasConceptScore W2187915989C86803240 @default.

• next