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• W2187946259 abstract "Background: Science-based wildlife management refies on genetic infor;nation to infer oO;Juiation connectivity and identify conservation units. Ti',e most commonly used genetic marker for characterizing animal biodiversity and identifying maternalineages is the mitochondrial genome. rv1:tochondria! genotyping figures prominently in conservation and rT'anagemer,t plans, with much of tr,e atten:ion focused on the non-coding dispiacemem CO) loop. We used massiveiy paraiiel multiplexed sequencing to sequence complete mitochondria: genomes frorT' 40 fishers, a i:hreatened carnivore that possesses :ow mitogenomic diversiDJ. This allowed us to test a key assumption of conservation genetiCS, specifically, that the O-Ioop accurately reflects genealogical relationships and variation of the iarger mitochondria: geno;ne. Results: Overal! mitogenomic divergence in 4shers is exceedingly with 66 segrega:ing sites and an average pairwise distance between genomes 0' 0.00088 across their aligned iength (16,290 bp). Estimates of variatio n and genealogical re:ationships from the displacement (0) loop region (299 are contradicted by the comolete mitochondrial genorr,e, as well as tile protein coding fraction of the mitochondrial genome. The sources of this contradiction trace primarily to the ;,ear-abserKe 0 'i'iUtations marking the 0-1000 region of one of the most divergen t lineages, and secor,dar:!y to independe'lc (recurent) mutations at two nucleotide position the O-ioop amplicon. Conclusions: Our swcy has two important imp:rcations. �irst, inferred genealogical reconstructions based on the fisner O-Ioop region contradict inferences based on the entire mitogenome to the point that the fJopuiations 0' greatest conservation concern cannot be accurately resolved. Whole-ge;,ome analysi s identifies Caiifornian haplotypes from the northern-most populations as distinctve, vvith a significant excess of amino acid changes that may be indicat've of mo!ecu!ar adaptation; O-Ioop sequences fail to identify this unique mitochondria: lineage. Second, the impact of recurrent muta:ion appears most acute in closely related haplotypes, due to the low level of evolut ionary signal (unique mutations that mark lineages) relative to evolutionary noise (recl.'rrent, shared mL.;tation in unre!ated haplotypes). For vvildiife managers, this means that the populatons of greatest conservation concern may be at the highest risk of being misidentified D-Ioop haplotyping. This message is timely because it highlights the new opportunities for oasing conservation aecisions on more accurate genetic information." @default.
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• W2187946259 date "2011-01-01" @default.
• W2187946259 modified "2023-09-26" @default.
• W2187946259 title "Mitochondrial genome sequences illuminate maternal lineages of conservation" @default.
• W2187946259 hasPublicationYear "2011" @default.
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