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- W2187947897 abstract "Aim: Melatonin is an endogenous hormon, which oscillates from pineal gland and affects through melatonin receptors (MT1 and MT2) denoting different physiologic roles, accountable to regulate biological rhythm. This study is to known first study to show the regulation of melatonin synthesis by the melatonin receptor expressions in pineal gland. Materials-Methods: 200-250 gr weighted, 50 male Sprague Dawley rats were being examined with 5 different (n=10, 12/12hr light/dark (L/D), 24/0hr, 0/24hr, 8/16 hr L/D, 16/8 hr L/D) cycles for one week. Plasma melatonin levels were measured with ELISA kits and pineal gland receptors’ level with “Real Time Polymerase Chain-Reaction (Real-Time PCR)”. For the statistical analysis; reallocation randomization test, One-way Anova, Mann-U tests were applied. Results: Plasma melatonin levels in 0/24hr L/D group were examined statistically higher than control group and 24/0 hr L/D loops applied group (p<0.05). In paralel with MT1 (p<0.001) and MT2 (p<0.005) receptor expressions were semanticly upregulated at dark but downregulated in light. Conclusion: As similar with pineal gland receptors, melatonin levels increased highest rank of 26 pg/ml in dark, the lowest rank of 10 pg/ml in light exposure, reflecting in pineal gland Gi-dependent melatonin receptor expressions detained melatonin level in a particular rank. This study revealing firstly that instead of signals of SCN, MT1 and MT2 receptor expressions may regulate the plasma melatonin levels and the circadian clock." @default.
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- W2187947897 date "2010-01-01" @default.
- W2187947897 modified "2023-10-05" @default.
- W2187947897 title "Regulation of MT1 and MT2 Receptors in Pineal Gland with Light/Dark Cycle: A Novel Approach" @default.
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