Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187949097> ?p ?o ?g. }
- W2187949097 abstract "Progenitor/stem cell (PSC) has shown great promise for generation in failing heart. Advances in PSC biology have greatly enhanced our understanding of how PSC self-renewal, migration, maintenance of stemness, and cell-fate commitment depend on the balance of complex signals in their microenvironment. Endogenous PSC exists within structural and functional units known as PSC niches, which play important roles in directing PSC behavior. Recent years have witnessed great progress in our understanding of the PSC niche in cardiovascular biology. PSC based therapy could lead to successful cardiac regeneration or repair. Realizing the potential of therapeutic strategies is based on 1) differentiation of the PSC into all of the cellular constituents of the heart; 2) release of paracrine/ autocrine factors from the PSC; 3) fusion of the PSC with the existing constituents of the heart; and 4) stimulation of endogenous repair (regeneration of PSC niches). Importantly, cardiac PSC niches contain supporting cells and these cell-cell interactions have crucial regulatory roles in PSC based therapy. These findings have important implications for heart development, bioengineering, and furthermore elucidate a broader dimension of PSC control within the niche toward cardiomyocyte phenotype." @default.
- W2187949097 created "2016-06-24" @default.
- W2187949097 creator A5041934647 @default.
- W2187949097 creator A5062054124 @default.
- W2187949097 creator A5082308725 @default.
- W2187949097 date "2012-01-01" @default.
- W2187949097 modified "2023-09-22" @default.
- W2187949097 title "Review Article Recent concepts for the roles of progenitor/stem cell niche in heart repair" @default.
- W2187949097 cites W1504660023 @default.
- W2187949097 cites W1810772665 @default.
- W2187949097 cites W1872140826 @default.
- W2187949097 cites W1968663723 @default.
- W2187949097 cites W1972782503 @default.
- W2187949097 cites W1973994763 @default.
- W2187949097 cites W1978172109 @default.
- W2187949097 cites W1979608640 @default.
- W2187949097 cites W1985164695 @default.
- W2187949097 cites W1991037959 @default.
- W2187949097 cites W1995701551 @default.
- W2187949097 cites W1997576345 @default.
- W2187949097 cites W2003502792 @default.
- W2187949097 cites W2007982994 @default.
- W2187949097 cites W2009545124 @default.
- W2187949097 cites W2010486643 @default.
- W2187949097 cites W2010653927 @default.
- W2187949097 cites W2015609204 @default.
- W2187949097 cites W2017610560 @default.
- W2187949097 cites W2022056325 @default.
- W2187949097 cites W2026749151 @default.
- W2187949097 cites W2032570745 @default.
- W2187949097 cites W2036632122 @default.
- W2187949097 cites W2039707890 @default.
- W2187949097 cites W2039748263 @default.
- W2187949097 cites W2040446110 @default.
- W2187949097 cites W2043457504 @default.
- W2187949097 cites W2046587551 @default.
- W2187949097 cites W2048507807 @default.
- W2187949097 cites W2050689355 @default.
- W2187949097 cites W2051945150 @default.
- W2187949097 cites W2067067950 @default.
- W2187949097 cites W2069019884 @default.
- W2187949097 cites W2069417165 @default.
- W2187949097 cites W2069500991 @default.
- W2187949097 cites W2072239613 @default.
- W2187949097 cites W2080185076 @default.
- W2187949097 cites W2094986197 @default.
- W2187949097 cites W2097675424 @default.
- W2187949097 cites W2099474957 @default.
- W2187949097 cites W2103540918 @default.
- W2187949097 cites W2105925116 @default.
- W2187949097 cites W2105988341 @default.
- W2187949097 cites W2106485710 @default.
- W2187949097 cites W2122616632 @default.
- W2187949097 cites W2123963701 @default.
- W2187949097 cites W2125914414 @default.
- W2187949097 cites W2125987139 @default.
- W2187949097 cites W2127114313 @default.
- W2187949097 cites W2128085444 @default.
- W2187949097 cites W2138977668 @default.
- W2187949097 cites W2141248581 @default.
- W2187949097 cites W2141376975 @default.
- W2187949097 cites W2142267227 @default.
- W2187949097 cites W2142721799 @default.
- W2187949097 cites W2149487482 @default.
- W2187949097 cites W2149792859 @default.
- W2187949097 cites W2152483372 @default.
- W2187949097 cites W2156712000 @default.
- W2187949097 cites W2157806433 @default.
- W2187949097 cites W2158626287 @default.
- W2187949097 cites W2158979552 @default.
- W2187949097 cites W2161304727 @default.
- W2187949097 cites W2166941736 @default.
- W2187949097 cites W2171998177 @default.
- W2187949097 cites W3147645180 @default.
- W2187949097 cites W2740048833 @default.
- W2187949097 hasPublicationYear "2012" @default.
- W2187949097 type Work @default.
- W2187949097 sameAs 2187949097 @default.
- W2187949097 citedByCount "0" @default.
- W2187949097 crossrefType "journal-article" @default.
- W2187949097 hasAuthorship W2187949097A5041934647 @default.
- W2187949097 hasAuthorship W2187949097A5062054124 @default.
- W2187949097 hasAuthorship W2187949097A5082308725 @default.
- W2187949097 hasConcept C10882517 @default.
- W2187949097 hasConcept C128240485 @default.
- W2187949097 hasConcept C1491633281 @default.
- W2187949097 hasConcept C153991713 @default.
- W2187949097 hasConcept C15729860 @default.
- W2187949097 hasConcept C164794517 @default.
- W2187949097 hasConcept C169760540 @default.
- W2187949097 hasConcept C170493617 @default.
- W2187949097 hasConcept C171056886 @default.
- W2187949097 hasConcept C189014844 @default.
- W2187949097 hasConcept C18903297 @default.
- W2187949097 hasConcept C201750760 @default.
- W2187949097 hasConcept C28328180 @default.
- W2187949097 hasConcept C54355233 @default.
- W2187949097 hasConcept C7876069 @default.
- W2187949097 hasConcept C81885089 @default.
- W2187949097 hasConcept C86803240 @default.