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- W2187967990 abstract "Diabetes mellitus is one of the most important public health problems worldwide. If undiagnosed or untreated, this pathology represents a systemic risk factor and offers unfavorable conditions for dental treatments, especially those requiring bone healing. Objectives: The purpose of this study is to evaluate histol ogically and histochemically the effect of bone marrow - derived mesenchymal stem cell therapy in enhancing bone repair in surgically extracted sockets of diabetic albino rats. Design: Thirty male Swiss Albino rats ranging from 200 to 250 g were used in this study. The experimental animals were randomly divided into three groups (10 animals each) . The first lower right molar of the rats was extracted under general anesthesia. G roup I acted as a control with surgical extracted sockets were left empty . Diabetes was induced by single intravenous injection of 60 mg/kg body wt streptozotocin (STZ) in the remaining 20 rats . The rats in the control group received a comparable injection of saline. The diabetic rats divided into two groups (10 animals each) : group II; diabetic rats with empty sockets were left to heal spontaneously. While group III; diabetic rats in which, bone marrow mesenchymal stem cells were introduced into their sockets. Sacrification of animals was done after different time intervals. The MSCs wer e harvested from rat bone marrow . The two sides of each mandible were separated. The specimens were processed, decalcified and stained with hematoxylin and eosin for histological examination and Masson's trichrome for detection of collagen fibers . Results: MSCs accelerated bone healing in third group , while, diabetes induced delay of bone healing along the second diabetic group. This acceleration was assessed histologically by the presence of mature collagen fiber bundles and early new bone formation in the MSCs group. Histomorphometric analysis revealed an increase in the area percentage of bone trabeculae in the MSCs treated sockets compared to the control and diabetic ones. Conclusions: In a rat model of streptozotocin - induced diabetes, application of bo ne marrow mesenchymal stem cells can significantly enhance bone healing and mineralization in their sockets ." @default.
- W2187967990 created "2016-06-24" @default.
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- W2187967990 date "2013-01-01" @default.
- W2187967990 modified "2023-09-27" @default.
- W2187967990 title "Evaluation of the Role of Bone Marrow - Derived Mesenchymal Stem Cells in Bone Regeneration of Dental Socket in Streptozotocin - Induced Diabetic Albino Rats ." @default.
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