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• W2187968429 abstract "Purpose: The aims of this review are 1) to consider the hypothesis that interstitial cystitis (IC) is not a single disease entity in all patients by reviewing the evidence for the presence of IC subtypes and for the comorbidity of various unexplained clinical conditions in some patients with IC, and 2) to describe recent results obtained in humans and in cats with severe feline IC (FIC) that suggest the presence of an underlying neuroendocrine abnormality. Materials and Methods: The IC literature concerning comorbidity with other disorders was reviewed and these findings were compared with those of investigators studying the comorbid disorders and comparable data on cats with FIC. Results: A significant overlap of symptoms exists among a number of unexplained clinical conditions and a common stress response pattern of increased sympathetic nervous system function in the absence of comparable activation of the hypothalamic-pituitary-adrenal axis occurs in a subset of patients with many of these conditions. A comparable pattern exists in cats with FIC, which also includes increased corticotropin releasing factor activity and decreased adrenocortical reserve. Conclusions: Further investigation of the stress response system of patients with IC seems merited, which may provide novel approaches to therapy in some patients. Interstitial cystitis (IC) is a chronic pelvic pain syndrome of unknown cause and no generally accepted treatment.1 IC symptoms include variable combinations of pain referable to the bladder, and increased frequency and urgency of urination. IC may affect more than 700,000 American women2 and a significant proportion of men diagnosed with sterile prostatitis or prostatodynia.3 The quality of life of patients with IC is significantly degraded. In 1 study they scored much lower than healthy control subjects in all 8 domains of health (p 0.001), as assessed by the Medical Outcomes Study Short Form-36 Health Survey.1 The aims of this review are 1) to consider the hypothesis that IC is not a single disease entity in all patients by reviewing the evidence for the presence of IC subtypes and for the comorbidity of various unexplained clinical conditions in some patients with IC, and 2) to describe recent results obtained in humans and in cats with severe feline IC (FIC) that suggest the presence of an underlying neuroendocrine abnormality. Two subtypes of IC are currently recognized based on cystoscopic evaluation of the bladder. In most patients only submucosal petechial hemorrhages (glomerulations) are observed (type I), whereas Hunner’s ulcers with or without glomerulations are identified in a minority (type II). These" @default.
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• W2187968429 date "2004-01-01" @default.
• W2187968429 modified "2023-09-27" @default.
• W2187968429 title "Review Articles COMORBIDITY OF INTERSTITIAL CYSTITIS WITH OTHER UNEXPLAINED CLINICAL CONDITIONS" @default.
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