FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2187979969> ?p ?o ?g. }

• W2187979969 abstract "Background: Doxorubicin is a potent chemotherapeutic drug The clinical usefulness of doxorubicin has been limited largely by the risk of cardiomyopathy and life-threatening heart failure. Cellular changes leading to this toxicity are suggested to be mediated through a druginduced increase oxidative stress. Aim: This study investigated the effects of aminophylline on doxorubicin-induced cardiotoxicity in rat due to its antioxidant property. Materials and methods: Thirty five healthy Wistar strain albino rats were used. They were divided randomly into 5 groups (7 animals in each group). All animals supplied with standard food during the experiment with an access of water. They were distributed as follow: first group (normal saline treated group, 1 ml/kg, i.p.) in six equal doses in alternative days over a period of 2 weeks and considered as control group. Second, doxorubicin treated group (2.5 mg/kg, i.p., in six equal doses in alternative days over a period of 2 weeks to make a total cumulative dose of 15 mg/kg, body weight). The third, fourth and fifth groups were treated with aminophylline in doses (10, 20 and 30 mg/kg, i.p.) respectively plus doxorubicin (one hour prior each administered dose of doxorubicin ). Blood samples were collected and used to determine the serum levels of cardiac biomarker cardiac specific troponin T in addition to oxidative stress parameters malondialdehyde (MDA) and superoxide dismutase (SOD). Results: In aminophylline plus doxorubicin treated groups serum levels of cardiac troponin T and MDA were significantly lower than those of doxorubicin-treated group, While plasma SOD was increase. These changes occurred in a dose-dependent manner. Conclusions: This suggests that aminophylline may have a role in the attenuation and prevention of the serious cardiac complications of doxorubicin." @default.
• W2187979969 created "2016-06-24" @default.
• W2187979969 creator A5016179243 @default.
• W2187979969 creator A5066453122 @default.
• W2187979969 creator A5068260051 @default.
• W2187979969 creator A5081204704 @default.
• W2187979969 date "2014-01-01" @default.
• W2187979969 modified "2023-09-22" @default.
• W2187979969 title "ROLE OF AMINOPHYLLINE ON DOXORUBICIN-INDUCED CARDIOTOXICITY IN ANIMAL MODEL" @default.
• W2187979969 cites W1599342152 @default.
• W2187979969 cites W1876532791 @default.
• W2187979969 cites W1977401243 @default.
• W2187979969 cites W1988079533 @default.
• W2187979969 cites W2003362694 @default.
• W2187979969 cites W2014133471 @default.
• W2187979969 cites W2015556432 @default.
• W2187979969 cites W2016532211 @default.
• W2187979969 cites W2017482077 @default.
• W2187979969 cites W201962119 @default.
• W2187979969 cites W2020901364 @default.
• W2187979969 cites W2030033672 @default.
• W2187979969 cites W2030926513 @default.
• W2187979969 cites W2033538830 @default.
• W2187979969 cites W2040850983 @default.
• W2187979969 cites W2048006918 @default.
• W2187979969 cites W2050036109 @default.
• W2187979969 cites W2060697601 @default.
• W2187979969 cites W2064781203 @default.
• W2187979969 cites W2074682565 @default.
• W2187979969 cites W2106926141 @default.
• W2187979969 cites W2112351355 @default.
• W2187979969 cites W2134579594 @default.
• W2187979969 cites W2145551323 @default.
• W2187979969 cites W2159448749 @default.
• W2187979969 cites W2162689981 @default.
• W2187979969 cites W2182560454 @default.
• W2187979969 cites W2288346129 @default.
• W2187979969 hasPublicationYear "2014" @default.
• W2187979969 type Work @default.
• W2187979969 sameAs 2187979969 @default.
• W2187979969 citedByCount "0" @default.
• W2187979969 crossrefType "journal-article" @default.
• W2187979969 hasAuthorship W2187979969A5016179243 @default.
• W2187979969 hasAuthorship W2187979969A5066453122 @default.
• W2187979969 hasAuthorship W2187979969A5068260051 @default.
• W2187979969 hasAuthorship W2187979969A5081204704 @default.
• W2187979969 hasConcept C115725540 @default.
• W2187979969 hasConcept C126322002 @default.
• W2187979969 hasConcept C151032500 @default.
• W2187979969 hasConcept C2776151105 @default.
• W2187979969 hasConcept C2776202631 @default.
• W2187979969 hasConcept C2776694085 @default.
• W2187979969 hasConcept C2777397205 @default.
• W2187979969 hasConcept C2778233292 @default.
• W2187979969 hasConcept C2778401633 @default.
• W2187979969 hasConcept C2781303535 @default.
• W2187979969 hasConcept C29730261 @default.
• W2187979969 hasConcept C42219234 @default.
• W2187979969 hasConcept C500558357 @default.
• W2187979969 hasConcept C71924100 @default.
• W2187979969 hasConcept C98274493 @default.
• W2187979969 hasConceptScore W2187979969C115725540 @default.
• W2187979969 hasConceptScore W2187979969C126322002 @default.
• W2187979969 hasConceptScore W2187979969C151032500 @default.
• W2187979969 hasConceptScore W2187979969C2776151105 @default.
• W2187979969 hasConceptScore W2187979969C2776202631 @default.
• W2187979969 hasConceptScore W2187979969C2776694085 @default.
• W2187979969 hasConceptScore W2187979969C2777397205 @default.
• W2187979969 hasConceptScore W2187979969C2778233292 @default.
• W2187979969 hasConceptScore W2187979969C2778401633 @default.
• W2187979969 hasConceptScore W2187979969C2781303535 @default.
• W2187979969 hasConceptScore W2187979969C29730261 @default.
• W2187979969 hasConceptScore W2187979969C42219234 @default.
• W2187979969 hasConceptScore W2187979969C500558357 @default.
• W2187979969 hasConceptScore W2187979969C71924100 @default.
• W2187979969 hasConceptScore W2187979969C98274493 @default.
• W2187979969 hasLocation W21879799691 @default.
• W2187979969 hasOpenAccess W2187979969 @default.
• W2187979969 hasPrimaryLocation W21879799691 @default.
• W2187979969 hasRelatedWork W1980896349 @default.
• W2187979969 hasRelatedWork W2010693387 @default.
• W2187979969 hasRelatedWork W2051190228 @default.
• W2187979969 hasRelatedWork W2080936300 @default.
• W2187979969 hasRelatedWork W2106756232 @default.
• W2187979969 hasRelatedWork W2150376471 @default.
• W2187979969 hasRelatedWork W2169557320 @default.
• W2187979969 hasRelatedWork W2185819837 @default.
• W2187979969 hasRelatedWork W2405230245 @default.
• W2187979969 hasRelatedWork W2574023248 @default.
• W2187979969 hasRelatedWork W2574877306 @default.
• W2187979969 hasRelatedWork W2888039538 @default.
• W2187979969 hasRelatedWork W3007047702 @default.
• W2187979969 hasRelatedWork W3013827858 @default.
• W2187979969 hasRelatedWork W3037650479 @default.
• W2187979969 hasRelatedWork W3106664289 @default.
• W2187979969 hasRelatedWork W3158885596 @default.
• W2187979969 hasRelatedWork W3196715930 @default.
• W2187979969 hasRelatedWork W2181688164 @default.
• W2187979969 hasRelatedWork W2553298922 @default.
• W2187979969 isParatext "false" @default.

• next