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- W2187993602 abstract "Keywords: MAPkinases signaling pathway, MAP4K4, cell motility, inflammation, cancer Abstract: MAP4K4 is a member of the germinal center kinase GCK-IV group and is involved in controlling cellular processes that include cell motility, rearrangement of the cytoskeleton and cell proliferation. MAP4K4 proved to be an upstream activator of the cJUN-n term inal kinases 1 and 2 (JNK1/2), extracellular signal-related kinase 1/2 (ERK1/2), and p38 SAP kinase. TNFand p53 are two of the most important factors that have the capacity to increase the expression of MAP4K4. MAP4K4 is involved in a very complex network of signaling pathways and interactions that are involved in diseases like diabetes or cancer. The recent findings place MAP4K4 as a novel target that may provide insights into new therapies, in the effort to prevent or even treat these diseases." @default.
- W2187993602 created "2016-06-24" @default.
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- W2187993602 date "2010-06-03" @default.
- W2187993602 modified "2023-09-24" @default.
- W2187993602 title "MAP4K4 A POSSIBLE NEW BIOMARKER IN CANCER THERAPY" @default.
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