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• W2188003205 abstract "Summary In the present investigation the activity levels of the enzyme cytochrome-P450 in different areas of rat brain were examined during administration of the synthetic opioid analgesic drug tramadol without induction of pain. Male adult Wistar rats were used in the study. Tramadol was injected subcutaneously, and the changes in CyP450 activity in cortex, cerebellum, ponsmedulla, hippocampus and hypothalamus of the brain were studied at 3, 6, 12 and 24 hours following administration of the drug (31 mg/kg body wt). The present study showed an increase in CyP450 activity in all areas of the brain by 6 hours following the injection of tramadol, and by 24 hours it returned more or less to the respective control levels. Maximal increase of enzyme activity levels was recorded in hippocampus followed by cortex, pons-medulla, cerebellum and hypothalamus. The results indicate that the levels of CyP450 get increased as a measure of metabolizing the drug for one-time administration of tramadol. However, the activity got reverted to control levels after the time limit of change, indicating that tramadol would not have any adverse affects on the brain and can be administrated safely during total absence of pain or non-induction of pain." @default.
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• W2188003205 date "2009-01-01" @default.
• W2188003205 modified "2023-09-24" @default.
• W2188003205 title "SAFETY OF TRAMADOL - CHANGES IN THE LEVELS OF MICROSOMAL CYP450 IN RAT BRAIN WITHOUT NOCICEPTION" @default.
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