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- W2188015892 abstract "Previous studies showed that thymoquinone, the main constituent of Nigella sativa, has bronchodilatory effects. So for determining its effect on endothelin 1 level, this study was proposed. Forty guinea pigs of both sexes were randomly divided to control (group C), animal model of asthma (group S) and sensitized groups drinking water containing 20 M thymoquinone (group S+LTQ) and 40 M thymoquinone (group S+HTQ). The mean value of endothelin in bronchoalveolar lavage and lung tissue of sensitized group was significantly higher than in group C (p<0.001 to p<0.01). The mean value of endothelin in bronchoalveolar lavage in pre-treated group with low and high concentrations of thymoquinone were significantly lower than S group (p<0.05). The mean value of endothelin in lung tissue of S+LTQ group was significantly lower than S group (p<0.05). There was not any significant difference between two pretreated groups. It confirmed thymoquinone has reducing effect on endothelin level in both bronchoalveolar lavage and lung tissue in asthmatic guinea pigs." @default.
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- W2188015892 date "2013-01-01" @default.
- W2188015892 modified "2023-09-26" @default.
- W2188015892 title "The Effect of Thymoquinone, the main Constituent of Nigella sativa, on Endothelin level of Ovalbumin Sensitized Guinea Pigs" @default.
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