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- W2188045987 abstract "Purpose: Disregulation of the cell cycle is required for the formation of various malignant tumors including gastric carcinoma. This study aimed to evaluate cell-cycle-regulators, p27 and p53, expression in gastric carcinoma by immunohistochemistry and to correlate their expression with other clinicopathological findings. Material and Methods: Eighty-four cases of gastric carcinoma were included in this study. They were classified into intestinal and diffuse types according to Lauren's classification. P27 and P53 expression were correlated with patient's age, histologic type, pathologic grade, lymph node metastasis and tumor tissue invasion. Results: There was non significant correlation between p27 and p53 expression with patient's age or histologic type of the tumor. Loss of expression of p27 was significantly correlated with pathologic grade, lymph node metastasis and tumor tissue invasion. P53 over-expression was more frequently detected in high grade tumors, tumors with lymph node metastasis and high t-stage, but the correlations were statistically non-significance. A significant inverse correlation was detected between p27 and p53 expression. Conclusion: Reduced expression of p27 may influence the progression and metastases to lymph node in gastric tumors. In addition, combined expression of cell-cycle regulators, p27 and p53, may play an important role in the biological behavior of human gastric carcinoma. (Naglaa Fathi Abbas, Sonia Labib El-Sharkawy, Mona Talaat Fadel, Marwa Abd El-Monem El-Shaer, Manal Abd El-Megid Badawi and Wafaa El-Said Abd El-Aal. Combined Expression of P27 and P53 in Human Gastric Carcinoma. Report and Opinion 2010;2(11):27-34). (ISSN: 1553-9873)." @default.
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- W2188045987 date "2010-01-01" @default.
- W2188045987 modified "2023-09-26" @default.
- W2188045987 title "Combined Expression of P27 and P53 in Human Gastric Carcinoma" @default.
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