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• W2188086223 abstract "Inflammation and tumor hypoxia are intimately linked and breast cancer provides a typical example of an inflammation-linked malignant disease. Indeed, breast cancer progression is actively supported by inflammatory components, including IL-1 β , and by the hypoxia-inducible factor- (HIF-) 1 α . In spite of many attempts where the role of either IL-1 β or HIF-1 α was evaluated, detailed mechanisms for their effects on breast cancer cell migration under hypoxia are still unclear. We here report that IL-1 β increased MDAMB231 cell migration under hypoxic conditions along with HIF-1 α accumulation and upregulation of CXCR1, which is transcriptionally regulated by HIF-1 α , as well as an increased expression of CXCL8 and NF κ B. In addition, IL-1 β -induced cell migration in hypoxia was not affected when HIF-1 α was inhibited by either siRNA or Topotecan, well known for its inhibitory effect on HIF-1 α . Of interest, HIF-1 α inhibition did not reduce NF κ B and CXCL8 expression and the reduction of IL-1 β -induced cell migration under hypoxia was achieved only by pharmacological inhibition of NF κ B. Our findings indicate that inhibition of HIF-1 α does not prevent the migratory program activated by IL-1 β in hypoxic MDAMB231 cells. They also suggest a potential compensatory role of NF κ B/CXCL8 pathway in IL-1 β -induced MDAMB231 cell migration in a hypoxic microenvironment." @default.
• W2188086223 created "2016-06-24" @default.
• W2188086223 creator A5019708105 @default.
• W2188086223 creator A5051860861 @default.
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• W2188086223 date "2015-01-01" @default.
• W2188086223 modified "2023-09-26" @default.
• W2188086223 title "Interleukin-1<i>β</i>Affects MDAMB231 Breast Cancer Cell Migration under Hypoxia: Role of HIF-1<i>α</i>and NF<i>κ</i>B Transcription Factors" @default.
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• W2188086223 doi "https://doi.org/10.1155/2015/789414" @default.
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