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- W2188118510 abstract "The new method described below, RP-HPLC (reversed phase - high performance liquid chromatography) on a cyanopropyl column, is a convenient and efficient but less explored alternative method for the separation and quantification of simvastatin and its impurities. The critical parameters for the newly developed method were studied, the final purpose being suitability assesment for the analysis of pharmaceutical dosage forms containing simvastastin. The optimum experimental conditions (Nucleosil column 100-5CN 125 x 4.6 mm i.d, with 5 µm particles, gradient elution with a mixture of water and acetonitrile; room temperature; 2.5 mL/min flow rate; UV detection-238 nm) for the separation and assay of simvastatin were established. Rezumat Metoda noua descrisa mai jos, cromatografie de lichide de inalta perfomanța cu faze inversate pe o coloana ciano-propil, este un procedeu alternativ convenabil si eficient, mai puţin utilizat pentru separarea si cuantificarea simvastatinei si impuritaţilor sale. Au fost studiaţi parametrii critici pentru noua metoda dezvoltata cu scopul final de a verifica adecvarea metodei la analiza formelor farmaceutice dozate care conțin simvastatina. Au fost stabilite condiţiile experimentale optime pentru separarea si dozarea simvastatinei (coloana Nucleosil 100-5CN 125 x 4,6 mm d.i., cu particule de 5 µm, eluție in gradient cu amestec de apa și acetonitril, la temperatura camerei, debitul fazei mobile 2,5 mL/min și detecție in UV la 238 nm)." @default.
- W2188118510 created "2016-06-24" @default.
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- W2188118510 date "2013-01-01" @default.
- W2188118510 modified "2023-09-27" @default.
- W2188118510 title "DEVELOPMENT OF A NEW LC METHOD FOR THE IDENTIFICATION, SEPARATION AND ASSAY OF SIMVASTATIN AND ITS IMPURITIES" @default.
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