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• W2188128532 abstract "Objective: In an attempt to improve the conception rates, artificial insemination techniques with misoprostol in various forms have been reported. The positive effect of vaginal misoprostol leading to an improved clinical pregnancy rate is not clearly understood. The known effects of prostaglandin E on increasing myometrial contractility and potential relaxation of tubal isthmus may all facilitate fertilization potential. We intended to investigate here the effects of misoprostol on pregnancy rates and the outcome of intrauterine insemination. Materials and Methods: All patients (age, ≤35 years), whose data on male and female diagnosis was available, were included in the study. The data of 34 cycles, determined as the control group, with either unexplained infertility or ovulatory dysfunction, having undergone therapeutic insemination in an effort to establish pregnancy were retrospectively studied. Prospectively, 33 cycles were randomized as the study group to ovulation induction followed by intrauterine insemination and vaginally administered 200 mg misoprostol at the time of insemination. Oral and injectable fertility drugs were administered. The cycles were monitored and endometrial thickness and follicular development were measured by transvaginal ultrasound. Both retrospective (control group) and prospective (study group) results were reviewed and analyzed and the pregnancy rates in intrauterine insemination recipients were compared. Results: In a retrospective analysis involving 34 inseminations in the control group, five pregnancies were recorded for an overall pregnancy rate of 13% per insemination (or cycle). In the follow-up prospective study (n: 33), four pregnancies were recorded and the pregnancy rate for the intrauterine insemination-misoprostol study group was 11% per cycle. There were two abortions in the misoprostol group while only one recorded in the control group. There was no difference between the couples of the two groups regarding their age; duration, type and cause of infertility. Conclusion: Because of the indefinite advantage and the higher miscarriage rates of misoprostol over pure cycles in our study, we cannot recommend presently the routine use of intravaginal misoprostol in intrauterine insemination cycles." @default.
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• W2188128532 date "2004-01-01" @default.
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• W2188128532 title "Evaluation of the Effects of Misoprostol on Pregnancy Rates Among Infertile Couples Undergoing Ovulation Induction and Intrauterine Insemination" @default.
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