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- W2188184176 abstract "Measles virus isolated fromthebrainofa patient withsubacute sclerosing panencephalitis wasinjected intracerebrally (ic) into34rhesus monkeys. Groupsof these animals wereinjected withmeasles antigen inFreund's complete adjuvant or treated byschedules usedforsuppression ofthegeneral orcell-mediated immune responsiveness. Inanother groupofanimals, experimental allergic encephalitis was induced parallel withmeasles infection. Measles virus was isolated fromthebrains ofmonkeys up to13daysafter icinoculation. Novirus was detected inthecentral nervoussystemafter 3to4weeks, thelongest postinoculation period examined. It was concluded thatthesubacute sclerosing panencephalitis-derived virus either lost its neurotropic properties atthepassagelevel atwhichitwas used orthat itsubmergedinto a silent stageandescaped detection. Neither immunosuppression nor concomitant autoimmune encephalitis hadan effect on thesurvival ofmeasles virus inthecentral nervoussystem. Thehistology ofthenervoustissue was basically normalexceptforcharacteristic lesions ofexperimental allergic encephalitis in animals receiving therespective treatment. Encephalitides inthepostinfectious period of several commonexanthematous diseases ofchildhoodorafter vaccination against rabies andsmallpoxarethought todepend largely onimmune reactions directed against brainantigens, viral antigens, orboth, inthebrain tissue proper (12, 21). Thefrequent failure toisolate aninfectious agent fromthecentral nervoussystem (CNS) in fatal cases ofencephalitis hassupported theabove view(21)." @default.
- W2188184176 created "2016-06-24" @default.
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- W2188184176 date "1971-01-01" @default.
- W2188184176 modified "2023-09-27" @default.
- W2188184176 title "Intracerebral Inoculation ofRhesus Monkeys witha Strain ofMeasles VirusIsolated froma Caseof Subacute Sclerosing Panencephalitis" @default.
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