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- W2188193427 abstract "The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis." @default.
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- W2188193427 date "2015-12-04" @default.
- W2188193427 modified "2023-10-15" @default.
- W2188193427 title "Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins" @default.
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- W2188193427 doi "https://doi.org/10.3390/molecules201219797" @default.
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