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- W2188202340 abstract "The hair follicle (HF) is central to most economica lly important fiber growth in livestock. However, the changes in expression of genes that dr ive these processes remain incompletely characterised. As model animal of hair biology, cas hmere goat might help deciphering genes involved in primary and secondary HF of skin. We used RNA-seq to study gene expression profiles of HF including anagen, catagen and teloge n in Nei Mongol Cashmere Goat (NMCG), which will increase our understanding of HF biology and contribute to the development of strategies to improve cashmere. Exome data from 7 secondary HFs and 11 primary HFs in NMCGs was mined. 22,176 annotated genes in reference genome were evaluated, 7481 of which were shown to be expressed in HFs. Join toget her, 1923 of 7481 were expressed in all HFs, 3219 and 2339 of which were co-expressed in primary and secondary HFs exclusively. GO analysis showed that GO: (0044464, 0003824, 0032501, 0032502) were associated gene sets. High expressed gene in secondary and primary HFs are mainly involved in 14 GO categories which included in above mentioned GO items. High expressed genes in two type HFs of 1923 are mainly located in CHI 7, 18 and 19 (p<0.01). Genes located in 4.6~4.9 Mb of CHI1 might be one gene cluster which has important function in HF development. Six SNPs related to hair follicle based on ~30K polymorphism loci different from reference, were functionally identified in CHI 1 and 19 respectivel y. Compare to secondary HF, primary HF expresses more genes to deal with stimulations from all-environment. Additionally, 13 HF specific expressed genes were identified according to comparative transcriptome (28) analysis." @default.
- W2188202340 created "2016-06-24" @default.
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- W2188202340 date "2013-08-26" @default.
- W2188202340 modified "2023-09-24" @default.
- W2188202340 title "Genes Involved in hair follicle cycle of cashmere goat" @default.
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